吉西他滨联合替吉奥术后辅助治疗对胰腺癌患者免疫功能及血清细胞迁移诱导透明质酸结合蛋白、Klotho的影响  

Effects of adjuvant therapy of gemcitabine combined with S-1 on immune function and serum cell migration inducing hyaluronidase 1 and Klotho in patients with pancreatic cancer

作　　者：刘绪林 刘桂举 LIU Xulin;LIU Guiju(Department of Pharmacy,the Fifth Clinical Medical College of He’nan University of Chinese Medicine(Zhengzhou People’s Hospital),Zhengzhou 450000,He’nan,China;Department of Oncology,the Fifth Clinical Medical College of He’nan University of Chinese Medicine(Zhengzhou People’s Hospital),Zhengzhou 450000,He’nan,China)

机构地区：[1]河南中医药大学第五临床医学院(郑州人民医院)药学部,郑州450000 [2]河南中医药大学第五临床医学院(郑州人民医院)肿瘤科,郑州450000

出　　处：《癌症进展》2023年第10期1086-1089,共4页Oncology Progress

摘　　要：目的探讨吉西他滨联合替吉奥术后辅助治疗对胰腺癌患者免疫功能及血清细胞迁移诱导透明质酸结合蛋白(CEMIP)、Klotho的影响。方法依据治疗方法的不同将80例胰腺癌患者分为观察组和对照组,每组40例,对照组患者给予吉西他滨治疗,观察者患者给予吉西他滨联合替吉奥治疗。比较两组患者血清肿瘤标志物[癌胚抗原(CEA)、糖类抗原125(CA125)、CEMIP、Klotho]水平、T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+))水平、不良反应发生情况和临床疗效。结果治疗后,两组患者CEA、CEMIP、CA125水平均低于本组治疗前,Klotho阳性表达率均高于本组治疗前,且观察组患者血清CEA、CEMIP、CA125水平均低于对照组,Klotho阳性表达率高于对照组,差异均有统计学意义(P﹤0.05)。治疗后,两组患者CD3^(+)、CD4^(+)水平均高于本组治疗前,CD8^(+)水平均低于本组治疗前,且观察组患者CD3^(+)、CD4^(+)水平均高于对照组,CD8^(+)水平低于对照组,差异均有统计学意义(P﹤0.05)。两组患者乏力、恶心、皮疹、黏膜炎发生率比较,差异均无统计学意义(P﹥0.05)。观察组患者的疾病控制率为85.00%,高于对照组患者的65.00%,差异有统计学意义(P﹤0.05)。结论胰腺癌患者术后给予吉西他滨联合替吉奥辅助化疗,可提高临床疗效,改善患者免疫功能和血清肿瘤标志物水平,安全性较高。Objective To investigate the effect of adjuvant therapy of gemcitabine combined with S-1 on immune function,serum cell migration inducing hyaluronidase 1(CEMIP)and Klotho in patients with pancreatic cancer.Method According to the different treatment methods,80 patients with pancreatic cancer were divided into observation group and control group,with 40 cases in each group.The patients in the control group were treated with gemcitabine,and the patients in the observer group were treated with gemcitabine combined with S-1.Compare the levels of serum tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),CEMIP,Klotho]levels,T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+)),adverse reactions,and clinical efficacy between two groups.Result After treatment,the levels of CEA,CEMIP,and CA125 in both groups were lower than those before the treatment,and the Klotho positive expression rate were higher than those before the treatment,in addition,the serum levels of CEA,CEMIP,and CA125 in the observation group were lower than those in the control group,and the Klotho positive expression rate was higher than that in the control group,the differences were statistically significant(P<0.05).After the treatment,the levels of CD3^(+)and CD4^(+)in the two groups were higher than those before the treatment,the levels of CD8^(+)were lower than those before the treatment,and the levels of CD3^(+)and CD4^(+)in the observation group were higher than those of the control group,and the level of CD8^(+)was lower than that in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in the incidence of fatigue,nausea,rash,and mucositis between the two groups(P>0.05).The disease control rate of the observation group was 85.00%,which was higher than 65.00% of the control group,and the difference was statistically significant(P<0.05).Conclusion Adjuvant chemotherapy with gemcitabine combined with S-1 after pancreatic cancer surgery can improve the clinical efficacy,immun

关 键 词：胰腺癌 吉西他滨 替吉奥 免疫功能 细胞迁移诱导透明质酸结合蛋白 

分 类 号：R735.9[医药卫生—肿瘤]