同步放化疗与单纯放疗治疗头颈部肿瘤患者的临床疗效及对外周血细胞水平和形态的影响  

Clinical efficacy of concomitant radiochemotherapy versus radiotherapy in patients with head and neck tumor and the effect on level and morphology of peripheral blood cell

作　　者：李丽丽[1] 刘洋 徐驰 LI Lili;LIU Yang;XU Chi(Department of Clinical Laboratory,Beijing Fengtai Youanmen Hospital,Beijing 100069,China)

机构地区：[1]北京丰台右安门医院检验科,北京100069

出　　处：《癌症进展》2023年第10期1103-1106,共4页Oncology Progress

摘　　要：目的探讨同步放化疗与单纯放疗治疗头颈部肿瘤患者的临床疗效及对外周血细胞水平和形态的影响。方法根据治疗方法的不同将155例头颈部肿瘤患者分为单纯放疗组(n=129,单纯放疗)和同步放化疗组(n=26,同步放化疗)。比较两组患者的临床疗效、外周血细胞水平、血细胞形态学变化及不良反应发生情况。结果同步放化疗组患者的总有效率高于单纯放疗组(P﹤0.05)。治疗后,两组患者白细胞、中性粒细胞、淋巴细胞、血小板水平均低于本组治疗前,同步放化疗组患者红细胞水平低于本组治疗前,同步放化疗组患者白细胞、中性粒细胞、淋巴细胞、红细胞、血小板水平均低于单纯放疗组,差异均有统计学意义(P﹤0.05)。治疗中,同步放化疗组患者未成熟粒细胞、核左移、小细胞比例均低于单纯放疗组,差异均有统计学意义(P﹤0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P﹥0.05)。结论对于头颈部肿瘤患者,同步放化疗的临床疗效优于单纯放疗,可有效降低外周血细胞水平,且治疗过程中不会增加不良反应发生率。Objective To investigate the clinical efficacy of concomitant radiochemotherapy versus radiotherapy in patients with head and neck tumor and the effect on level and morphology of peripheral blood cell.Method A total of 155 patients with head and neck tumor were divided into the radiotherapy group(n=129,radiotherapy alone)and the concomitant radiochemotherapy group(n=26,concomitant radiochemotherapy)according to different treatment methods.The clinical efficacy,peripheral blood cell levels,changes in cell morphology and adverse reactions were compared between the two groups.Result The total effective rate of the concomitant radiochemotherapy group was significantly higher than that of the radiotherapy group(P<0.05).After treatment,the levels of white blood cell,neutrophil,lymphocyte and platelet in both groups were lower than those before treatment,the level of erythrocyte in the concomitant radiochemotherapy group was lower than that before treatment,the levels of white blood cell,neutrophil,lymphocyte,erythrocyte and platelet in the concomitant radiochemotherapy group were lower than those in the radiotherapy group,and the differences were statistically significant(P<0.05).During treatment,the proportion of immature granulocytes,left nuclear shift and small cells in the concomitant radiochemotherapy group were lower than those in the radiotherapy group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The clinical efficacy of concomitant radiochemotherapy for head and neck tumor is better than that of radiotherapy,which can reduce the peripheral blood cell levels without increasing the risk of adverse reactions during treatment.

关 键 词：头颈部肿瘤 同步放化疗 单纯放疗 外周血细胞形态 

分 类 号：R739.91[医药卫生—肿瘤]