肠缺血/再灌注致远隔器官损伤相关机制的研究进展  

Research advances in the study of mechanisms associated with intestinal ischemia reperfusion injury causing distant organ injury

作　　者：曹璐 王迎斌[2] 张伟[2] 张丽[1] 刘艳 宁舒鹏[2] Cao Lu;Wang Yingbin;Zhang Wei;Zhang Li;Liu Yan;Ning Shupeng(The Second Clinical Medical School,Lanzhou University,Lanzhou 730030,China;Department of Anesthesiology,Lanzhou UniversitySecond Hospital,Lanzhou 730030,China)

机构地区：[1]兰州大学第二临床医学院,兰州730030 [2]兰州大学第二医院麻醉科,兰州730030

出　　处：《国际麻醉学与复苏杂志》2023年第6期667-672,共6页International Journal of Anesthesiology and Resuscitation

基　　金：甘肃省自然科学基金(22JR5RA976);兰州大学第二医院"萃英科技创新"计划(CY2022-MS-A20)。

摘　　要：肠缺血再灌注损伤(intestinal ischemia reperfusion injury,IIRI)是临床危重症患者常见并发症之一。IIRI相关机制研究表明,在IIRI过程中,肠黏膜屏障受损,细菌易位导致活性氧、炎症因子大量产生并释放入循环系统,可造成全身性炎症反应和肺、肝、肾等远隔器官功能障碍。文章阐述了肠缺血再灌注(intestinal ischemia reperfusion,IIR)引起肠外器官损伤的相关机制,为进一步探究IIR致多器官损伤机制、寻求靶向干预的多器官保护策略提供思路。Intestinal ischemia reperfusion injury(IIRI)is a common complication in clinically critically ill patients.The re⁃sults of these studies have shown that during IIRI,the intestinal mucosal barrier is damaged and bacterial translocation leads to the production and release of reactive oxygen species and inflammatory factors into the circulatory system,which can cause systemic in⁃flammation and dysfunction of distant organs such as lungs,liver,and kidneys.The article illustrates the mechanism of extra⁃intestinal organ damage caused by intestinal ischemia reperfusion and provides ideas for further investigation of the mechanism of multiple organ damage caused by intestinal ischemia reperfusion and the search for a multi⁃organ protection strategy with targeted intervention.

关 键 词：缺血再灌注 肠 远隔器官 

分 类 号：R574[医药卫生—消化系统]