激活转录因子2在宫颈癌患者中的表达及临床意义  

Expression and clinical significance of activating transcription factor 2 in patients with cervical cancer

作　　者：喻长法[1] 叶丽君[1] 蔡莎莎[1] 蒋亚萍[1] YU Chang-fa;YE Li-jun;CAI Sha-sha;JIANG Ya-ping(The First People's Hospital of Taizhou,Zhejiang 318020,China)

机构地区：[1]台州市第一人民医院,浙江318020

出　　处：《中国卫生检验杂志》2023年第10期1220-1222,共3页Chinese Journal of Health Laboratory Technology

基　　金：台州市科技局课题(21ywb53)。

摘　　要：目的 探讨激活转录因子2(ATF2)在宫颈癌患者中的表达及临床意义。方法 收集2018年11月—2022年6月在台州市第一人民医院住院的宫颈癌患者的组织标本,采用实时荧光定量PCR法检测ATF2的表达水平,用免疫组化染色法检测ATF2蛋白的表达。使用SPSS 22.0软件对结果进行统计学分析。结果 宫颈癌组ATF2 mRNA表达水平高于癌旁组,宫颈癌组ATF2蛋白的阳性率高于癌旁组(P<0.05)。ATF2的表达与TNM分期、分化程度和淋巴结转移等有关(P<0.05)。Kaplan-Meier生存分析显示,ATF2低表达组比高表达组有更好的累积生存率(P<0.05)。多因素Cox回归分析表明,低分化、Ⅲ/Ⅳ期、有淋巴结转移和ATF2高表达均为影响宫颈癌患者预后的独立危险因素(P<0.05)。结论 ATF2在宫颈癌组织中表达上调,与宫颈癌的发生发展有关。Objective This paper aims to investigate the expression and clinical significance of activating transcription factor 2(ATF2) in patients with cervical cancer.Methods Tissue samples of cervical cancer in patients hospitalized in the First People's Hospital of Taizhou from November 2018 to June 2022 were collected.Real-time fluorescent quantitative PCR was used to detect the expression of ATF2,and immunohistochemical staining was used to detect the expression of ATF2 protein.SPSS 22.0 software was used to analyze the results statistically.Results The level of ATF2 mRNA and the positive rate of ATF2 in the cervical cancer group were both higher than that of the adjacent group(P<0.05).The expression of ATF2 was related to TNM staging,differentiation degree and lymph node metastasis(P<0.05).Kaplan-Meier survival analysis showed that the low ATF2 expression group had a higher cumulative survival rate than the high ATF2 expression group(P<0.05).Multivariate Cox regression analysis showed that low differentiation,stage Ⅲ/Ⅳ,lymph node metastasis and high expression of ATF2 were independent risk factors for the prognosis of cervical cancer patients(P<0.05).Conclusion ATF2 is highly expressed in cervical cancer tissues,which is related to the occurrence and development of cervical cancer.

关 键 词：激活转录因子2 宫颈癌 表达 

分 类 号：R737.33[医药卫生—肿瘤]