Intrahepatic cholangiocarcinoma in patients with primary sclerosing cholangitis and ulcerative colitis: Two case reports  

作　　者：Takahiro Miyazu Natsuki Ishida Yusuke Asai Satoshi Tamura Shinya Tani Mihoko Yamade Moriya Iwaizumi Yasushi Hamaya Satoshi Osawa Satoshi Baba Ken Sugimoto 

机构地区：[1]First Department of Medicine,Hamamatsu University School of Medicine,Hamamatsu 431-3192,Japan [2]Department of Endoscopic and Photodynamic Medicine,Hamamatsu University School of Medicine,Hamamatsu 431-3192,Japan [3]Department of Laboratory Medicine,Hamamatsu University School of Medicine,Hamamatsu 431-3192,Japan [4]Department of Diagnostic Pathology,Hamamatsu University School of Medicine,Hamamatsu 431-3192,Japan

出　　处：《World Journal of Gastrointestinal Surgery》2023年第6期1224-1231,共8页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND Primary sclerosing cholangitis(PSC)is an extraintestinal manifestation of ulcerative colitis(UC).PSC is a well-known risk factor for intrahepatic cholangiocarcinoma(ICC),and ICC is known to have a poor prognosis.CASE SUMMARY We present two cases of ICC in patients with PSC associated with UC.In the first case,a tumor was found by magnetic resonance imaging(MRI)in the liver of a patient with PSC and UC who presented to our hospital with right-sided rib pain.The second patient was asymptomatic,but we unexpectedly detected two liver tumors in an MRI performed to evaluate bile duct stenosis associated with PSC.ICC was strongly suspected by computed tomography and MRI in both cases,and surgery was performed,but unfortunately,the first patient died of ICC recurrence 16 mo postoperatively,and the second patient died of liver failure 14 mo postoperatively.CONCLUSION Careful follow-up of patients with UC and PSC with imaging and blood tests is necessary for early detection of ICC.

关 键 词：Ulcerative colitis Primary sclerosing cholangitis Intrahepatic cholangiocarcinoma Hepatic lobectomy Inflammatory bowel disease Case report 

分 类 号：R735.8[医药卫生—肿瘤]