Haemodynamic management in brain death donors:Influence of aetiology of brain death  

作　　者：Chiara Lazzeri Manuela Bonizzoli Stefano Batacchi Cristiana Guetti Walter Vessella Alessandra Valletta Alessandra Ottaviano Adriano Peris 

机构地区：[1]Department of Emergency,Intensive Care Unit and Extracorporeal Membrane Oxygenation Center,Florence 50134,Italy

出　　处：《World Journal of Transplantation》2023年第4期183-189,共7页世界移植杂志

摘　　要：BACKGROUND In brain death donors(BDDs),donor management is the key in the complex donation process.Donor management goals,which are standards of care or clinical parameters,have been considered an acceptable barometer of successful donor management.AIM To test the hypothesis that aetiology of brain death could influence haemodynamic management in BDDs.METHODS Haemodynamic data(blood pressure,heart rate,central venous pressure,lactate,urine output,and vasoactive drugs)of BDDs were recorded on intensive care unit(ICU)admission and during the 6-h observation period(Time 1 at the beginning;Time 2 at the end).RESULTS The study population was divided into three groups according to the aetiology of brain death:Stroke(n=71),traumatic brain injury(n=48),and postanoxic encephalopathy(n=19).On ICU admission,BDDs with postanoxic encephalopathy showed the lowest values of systolic and diastolic blood pressure associated with higher values of heart rate and lactate and a higher need of norepinephrine and other vasoactive drugs.At the beginning of the 6-h period(Time 1),BDDs with postanoxic encephalopathy showed higher values of heart rate,lactate,and central venous pressure together with a higher need of other vasoactive drugs.CONCLUSION According to our data,haemodynamic management of BDDs is affected by the aetiology of brain death.BDDs with postanoxic encephalopathy have higher requirements for norepinephrine and other vasoactive drugs.

关 键 词：Brain death donor Postanoxic encephalopathy STROKE Acute traumatic injury Haemodynamic management Utilization rate 

分 类 号：R74[医药卫生—神经病学与精神病学]