Clinical value of serum pepsinogen in the diagnosis and treatment of gastric diseases  

作　　者：Yuan Qin Jia-Xin Geng Biao Huang 

机构地区：[1]College of Life Sciences and Medicine,Zhejiang Sci-Tech University,Hangzhou 310018,Zhejiang Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2023年第7期1174-1181,共8页世界胃肠肿瘤学杂志（英文版）（电子版）

基　　金：Supported by the National Natural Science Foundation of China,No.82172336;“Pioneer”and“Leading Goose”R&D Program of Zhejiang,No.2022C03118 and No.2023C03075;Natural Science Foundation of Zhejiang Province,No.LQ23H050005;Scientific Research Project of Zhejiang Provincial Education Department,No.Y202250731.

摘　　要：Pepsinogen,secreted from the gastric mucosa,is the precursor of pepsin.It is categorized as pepsinogen 1 and pepsinogen 2 based on its immunogenicity.The pepsinogen content that can enter the blood circulation through the capillaries of the gastric mucosa is approximately 1%and remains stable all the time.The pepsinogen content in serum will change with the pathological changes of gastric mucosa.Therefore,the level of pepsinogen in serum can play a role in serologic biopsy to reflect the function and morphology of different regions of gastric mucosa and serve as an indicator of gastric disease.This study conducts relevant research on serum pepsinogen 1,pepsinogen 2,and the ratio of pepsinogen 1 to pepsinogen 2,and reviews their important value in clinical diagnosis of Helicobacter pylori infection,gastric ulcer,and even gastric carcinoma,providing ideas for other researchers.

关 键 词：Pepsinogen 1 Pepsinogen 2 Gastric diseases Serological marker Serological biopsy 

分 类 号：R573[医药卫生—消化系统]