Efficacy of continuous gastric artery infusion chemotherapy in relieving digestive obstruction in advanced gastric cancer  

作　　者：Rui Tang Guo-Feng Chen Kai Jin Guang-Qiang Zhang Jian-Jun Wu Shu-Gao Han Bin Li Ming Chao 

机构地区：[1]Department of Radiology,The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310000,Zhejiang Province,China [2]Department of Gastrointestinal Surgery,The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310000,Zhejiang Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2023年第7期1283-1294,共12页世界胃肠肿瘤学杂志（英文版）（电子版）

基　　金：The study was reviewed and approved by the Ethics Committee of The Second Affiliated Hospital of Zhejiang University School of Medicine(Approval No.I2020001737).

摘　　要：BACKGROUND Obstruction or fullness after feeding is common in gastric cancer(GC)patients,affecting their nutritional status and quality of life.Patients with digestive obstruction are generally in a more advanced stage.Existing methods,including palliative gastrectomy,gastrojejunostomy,endoluminal stent,jejunal nutrition tube and intravenous chemotherapy,have limitations in treating these symptoms.AIM To analyze the efficacy of continuous gastric artery infusion chemotherapy(cGAIC)in relieving digestive obstruction in patients with advanced GC.METHODS This study was a retrospective study.Twenty-nine patients with digestive obstruction of advanced GC who underwent at least one cycle of treatment were reviewed at The Second Affiliated Hospital of Zhejiang University School of Medicine.The oxaliplatin-based intra-arterial infusion regimen was applied in all patients.Mild systemic chemotherapy was used in combination with local treatment.The clinical response was evaluated by contrast-enhanced computed tomography using Response Evaluation Criteria In Solid Tumors(RECIST)criteria.Digestive tract symptoms and toxic effects were analyzed regularly.A comparison of the Karnofsky Performance Status(KPS)score and Stooler’s Dysphagia Score before and after therapy was made.Univariate survival analysis and multivariate survival analysis were also performed to explore the key factors affecting patient survival.RESULTS All patients finished cGAIC successfully without microcatheter displacement,as confirmed by arteriography.The median follow-up time was 24 mo(95%CI:20.24-27.76 mo).The overall response rate was 89.7%after cGAIC according to the RECIST criteria.The postoperative Stooler’s Dysphagia Score was significantly improved.Twentytwo(75.9%)of the 29 patients experienced relief of digestive obstruction after the first two cycles,and 13(44.8%)initially unresectable patients were then considered radically resectable.The median overall survival time(mOS)was 16 mo(95%CI:9.32-22.68 mo).Patients who received radical surgery ha

关 键 词：Intra-arterial infusion chemotherapy Intravenous chemotherapy Interventional radiology Digestive obstruction Advanced gastric cancer Response evaluation criteria in solid tumors 

分 类 号：R735.2[医药卫生—肿瘤]