Vitamin E in the management of pancreatic cancer: A scoping review  

作　　者：Sophia Ogechi Ekeuku Effiong Paul Etim Kok-Lun Pang Kok-Yong Chin Chun-Wai Mai 

机构地区：[1]Department of Pharmacology,Faculty of Medicine,Universiti Kebangsaan Malaysia,Kuala Lumpur 56000,Malaysia [2]Faculty of Applied Sciences,UCSI University,Kuala Lumpur 56000,Malaysia [3]Newcastle University Medicine Malaysia,Iskandar Puteri 79200,Johor,Malaysia [4]State Key Laboratory of Oncogenes and Related Genes,Renji-Med X Clinical Stem Cell Research Center,Ren Ji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China [5]Department of Pharmaceutical Chemistry,Faculty of Pharmaceutical Sciences,UCSI University,Kuala Lumpur 56000,Malaysia

出　　处：《World Journal of Gastrointestinal Oncology》2023年第6期943-958,共16页世界胃肠肿瘤学杂志（英文版）（电子版）

摘　　要：Pancreatic cancer is the leading cause of cancer mortality worldwide.Research investigating effective management strategies for pancreatic cancer is ongoing.Vitamin E,consisting of both tocopherol and tocotrienol,has demonstrated debatable effects on pancreatic cancer cells.Therefore,this scoping review aims to summarize the effects of vitamin E on pancreatic cancer.In October 2022,a literature search was conducted using PubMed and Scopus since their inception.Original studies on the effects of vitamin E on pancreatic cancer,including cell cultures,animal models and human clinical trials,were considered for this review.The literature search found 75 articles on this topic,but only 24 articles met the inclusion criteria.The available evidence showed that vitamin E modulated proliferation,cell death,angiogenesis,metastasis and inflammation in pancreatic cancer cells.However,the safety and bioavailability concerns remain to be answered with more extensive preclinical and clinical studies.More in-depth analysis is necessary to investigate further the role of vitamin E in the management of pancreatic cancers.

关 键 词：Anti-cancer treatment Pancreatic cancer Scoping review TOCOPHEROL TOCOTRIENOL Vitamin E 

分 类 号：R735.9[医药卫生—肿瘤]