CK5/6-positive,P63-positive lymphoepithelioma-like hepatocellular carcinoma:A case report and literature review  

作　　者：Hong-Tao Tang Wei Lin Wei-Qiao Zhang Jun-Lin Qian Kai Li Kun He 

机构地区：[1]Graduate School of Guangdong Medical University,Zhanjiang 524002,Guangdong Province,China [2]Department of Hepatobiliary Surgery,Zhongshan People’s Hospital,Zhongshan 528400,Guangdong Province,China

出　　处：《World Journal of Clinical Cases》2023年第19期4640-4647,共8页世界临床病例杂志

基　　金：Supported by Zhongshan Bureau of Science and Technology,No.2017B1044;and No.2017SYF04.

摘　　要：BACKGROUND Lymphoepithelioma-like carcinoma(LELC),a rare and unique variant of liver cancer,can be divided into lymphoepithelioma-like hepatocellular carcinoma and lymphoepithelioma-like intrahepatic cholangiocarcinoma.Dense lymphocytic infiltration is its characteristic pathological feature.In recent years,the number of reported cases of this type has increased each year.Studies have shown that lymphoepithelioma-like cholangiocarcinoma occurs more frequently in Asian women;LELC is associated with Epstein–Barr virus infection of liver cells of epithelial origin.Existing research shows that the prognosis of this tumour is good.CASE SUMMARY A 38-year-old female patient was hospitalized after 3 mo of abdominal pain and nausea.She had been infected with hepatitis B virus more than 10 years prior.The patient was hospitalized on January 21,2022.Magnetic resonance imaging showed a 36 mm×28 mm mass under the envelope of the left inner lobe of the liver.No metastasis of lymph nodes or other organs was observed.After left hemihepatectomy,biopsy and immunohistochemistry yielded a final diagnosis of lymphoepithelial hepatocellular carcinoma.After 12 mo of outpatient follow-up and chemotherapy,no tumour metastases were found on the latest computed tomography examination.CONCLUSION Herein,the patient was treated surgically and then followed up as an outpatient for 12 mo.This case will further expand our overall knowledge of the diagnosis and treatment of this rare tumor.

关 键 词：Liver cancer Lymphoepithelioma-like carcinoma Hepatocellular carcinoma Epstein–Barr virus Literature review Case report 

分 类 号：R735.7[医药卫生—肿瘤]