Food contaminants and potential risk of diabetes development:A narrative review  

作　　者：Maja Milanovic Natasa Milosevic Natasa Milic Milica Medic Stojanoska Edward Petri Jelena Markovic Filipovic 

机构地区：[1]Department of Pharmacy,Faculty of Medicine,University of Novi Sad,Novi Sad 21000,Serbia [2]Faculty of Medicine,Clinic for Endocrinology,Diabetes and Metabolic Diseases,University Clinical Center of Vojvodina,University of Novi Sad,Novi Sad 21000,Serbia [3]Department of Biology and Ecology,Faculty of Sciences,University of Novi Sad,Novi Sad 21000,Serbia

出　　处：《World Journal of Diabetes》2023年第6期705-723,共19页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by the Ministry of Education,Science and Technological Development of the Republic of Serbia,451-03-68/2022-14/200125;Provincial Secretariat for Higher Education and Scientific Research,AP Vojvodina,Republic of Serbia,142-451-3120/2022-01.

摘　　要：The number of people diagnosed with diabetes continues to increase,especially among younger populations.Apart from genetic predisposition and lifestyle,there is increasing scientific and public concern that environmental agents may also contribute to diabetes.Food contamination by chemical substances that originate from packaging materials,or are the result of chemical reactions during food processing,is generally recognized as a worldwide problem with potential health hazards.Phthalates,bisphenol A(BPA)and acrylamide(AA)have been the focus of attention in recent years,due to the numerous adverse health effects associated with their exposure.This paper summarizes the available data about the association between phthalates,BPA and AA exposure and diabetes.Although their mechanism of action has not been fully clarified,in vitro,in vivo and epidemiological studies have made significant progress toward identifying the potential roles of phthalates,BPA and AA in diabetes development and progression.These chemicals interfere with multiple signaling pathways involved in glucose and lipid homeostasis and can aggravate the symptoms of diabetes.Especially concerning are the effects of exposure during early stages and the gestational period.Well-designed prospective studies are needed in order to better establish prevention strategies against the harmful effects of these food contaminants.

关 键 词：ACRYLAMIDE Bisphenol A PHTHALATES Endocrine disrupting chemicals β-cell DIABETES 

分 类 号：R155.5[医药卫生—营养与食品卫生学] R587.1[医药卫生—公共卫生与预防医学]