Adiponectin as a therapeutic target for diabetic foot ulcer  

作　　者：Mona Mohamed Ibrahim Abdalla Jaiprakash Mohanraj Sushela Devi Somanath 

机构地区：[1]Department of Physiology,Human Biology Division,School of Medicine,International Medical University,Kuala Lumpur 57000,Malaysia [2]Department of Biochemistry,Human Biology Division,School of Medicine,International Medical University,Kuala Lumpur 57000,Malaysia [3]Department of Microbiology,School of Medicine,International Medical University,Kuala Lumpur 57000,Malaysia

出　　处：《World Journal of Diabetes》2023年第6期758-782,共25页世界糖尿病杂志（英文版）（电子版）

摘　　要：The global burden of diabetic foot ulcers(DFUs)is a significant public health concern,affecting millions of people worldwide.These wounds cause considerable suffering and have a high economic cost.Therefore,there is a need for effective strategies to prevent and treat DFUs.One promising therapeutic approach is the use of adiponectin,a hormone primarily produced and secreted by adipose tissue.Adiponectin has demonstrated anti-inflammatory and antiatherogenic properties,and researchers have suggested its potential therapeutic applications in the treatment of DFUs.Studies have indicated that adiponectin can inhibit the production of pro-inflammatory cytokines,increase the production of vascular endothelial growth factor,a key mediator of angiogenesis,and inhibit the activation of the intrinsic apoptotic pathway.Additionally,adiponectin has been found to possess antioxidant properties and impact glucose metabolism,the immune system,extracellular matrix remodeling,and nerve function.The objective of this review is to summarize the current state of research on the potential role of adiponectin in the treatment of DFUs and to identify areas where further research is needed in order to fully understand the effects of adiponectin on DFUs and to establish its safety and efficacy as a treatment for DFUs in the clinical setting.This will provide a deeper understanding of the underlying mechanisms of DFUs that can aid in the development of new and more effective treatment strategies.

关 键 词：Diabetic foot ulcer ADIPONECTIN ANTI-INFLAMMATORY Adipose tissue ANTIOXIDANTS Wound healing 

分 类 号：R587.2[医药卫生—内分泌]