Abnormal volumetric brain morphometry and cerebral blood flow in adolescents with depression  

作　　者：Yu-Jia Fu Xiao Liu Xing-Yu Wang Xiao Li Lin-Qi Dai Wen-yu Ren Yong-Ming Zeng Zhen-Lin Li Ren-Qiang Yu 

机构地区：[1]Department of Radiology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China [2]Department of Psychiatry,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China [3]Department of Radiology,Chongqing HongRen Yi Hospital,Chongqing 408400,China [4]Department of Radiology,West China Hospital,Chengdu 610041,Sichuan Province,China

出　　处：《World Journal of Psychiatry》2023年第6期386-396,共11页世界精神病学杂志

基　　金：Supported by The Project of Scientific Research and Innovative Experiment for College Students in Chongqing Medical University,No.202215;the Provincial Project of University Students Innovation and Entrepreneurship Training Program,No.202210631015.

摘　　要：BACKGROUND Prior research has demonstrated that the brains of adolescents with depression exhibit distinct structural alterations.However,preliminary studies have documented the pathophysiological changes in certain brain regions,such as the cerebellum,highlighting a need for further research to support the current understanding of this disease.AIM To study brain changes in depressed adolescents.METHODS This study enrolled 34 adolescents with depression and 34 age-,sex-,and education-level-matched healthy control(HC)individuals.Structural and functional alterations were identified when comparing the brains of these two participant groups through voxel-based morphometry and cerebral blood flow(CBF)analysis,respectively.Associations between identified brain alterations and the severity of depressive symptoms were explored through Pearson correlation analyses.RESULTS The cerebellum,superior frontal gyrus,cingulate gyrus,pallidum,middle frontal gyrus,angular gyrus,thalamus,precentral gyrus,inferior temporal gyrus,superior temporal gyrus,inferior frontal gyrus,and supplementary motor areas of adolescents with depression showed an increase in brain volume compared to HC individuals.These patients with depression further presented with a pronounced drop in CBF in the left pallidum(group=98,and peak t=-4.4324),together with increased CBF in the right percental gyrus(PerCG)(group=90,and peak t=4.5382).In addition,17-item Hamilton Depression Rating Scale scores were significantly correlated with the increased volume in the opercular portion of the left inferior frontal gyrus(r=-0.5231,P<0.01).CONCLUSION The right PerCG showed structural and CBF changes,indicating that research on this part of the brain could offer insight into the pathophysiological causes of impaired cognition.

关 键 词：Voxel-based morphometry Cerebral blood flow Arterial spin labeling ADOLESCENT DEPRESSION The right percental gyrus 

分 类 号：R749.4[医药卫生—神经病学与精神病学]