Epstein-Barr virus-induced infection-associated hemophagocytic lymphohistiocytosis with acute liver injury:A case report  

作　　者：Fang-Yuan Sun Bing-Qing Ouyang Xiao-Xiao Li Tao Zhang Wen-Tao Feng Yao-Guo Han 

机构地区：[1]Trauma Emergency Center,The Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China

出　　处：《World Journal of Clinical Cases》2023年第17期4090-4097,共8页世界临床病例杂志

基　　金：Supported by the National Natural Science Foundation of China,No.82174189;Talents Training Program of Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine,No.JCR2022-01;TCM Specialist Disease Alliance Construction Project of Shanghai Municipal Health Commission,No.ZY(2021-2023)-0302;Talent Training Project of Senior Master of Chinese Medicine of Shanghai Pudong,No.PDZY-2022-0601;Project of Introducing Senior Talents of Chinese Medicine of Shanghai Pudong,No.PDZY-2022-0701;Talents Training Program of the Seventh People’s Hospital,Shanghai University of Traditional Chinese Medicine,No.QMX2021-04.

摘　　要：BACKGROUND Hemophagocytic lymphohistiocytosis(HLH)is a severe hyperinflammatory reaction,which is rare and life-threatening.According to the pathogen,HLH is divided into genetic and acquired.The most common form of acquired HLH is infection-associated HLH,of which Herpes viruses,particularly Epstein-Barr virus(EBV),are the leading infectious triggers.However,it is difficult to distinguish between simple infection with EBV and EBV-induced infectionassociated HLH since both can destroy the whole-body system,particularly the liver,thereby increasing the difficulty of diagnosis and treatment.CASE SUMMARY This paper elaborates a case about EBV-induced infection-associated HLH and acute liver injury,aiming to propose clinical guides for the early detection and treatment of patients with EBV-induced infection-associated HLH.The patient was categorized as acquired hemophagocytic syndrome in adults.After the ganciclovir antiviral treatment combined with meropenem antibacterial therapy and methylprednisolone inhibition to inflammatory response,gamma globulin enhanced immunotherapy,the patient recovered.CONCLUSION From the diagnosis and treatment of this patient,attention should be paid to routine EBV detection and a further comprehensive understanding of the disease as well as early recognition and early initiation are keys to patients’survival.

关 键 词：Epstein-Barr virus Hemophagocytic lymphohistiocytosis Computed tomography Case report 

分 类 号：R575[医药卫生—消化系统] R551.2[医药卫生—内科学] R511[医药卫生—临床医学]