Synchronous endometrial and ovarian cancer: A case report  

作　　者：DianaŽilovič RūtaČiurlienė EvelinaŠidlovska Ieva Vaicekauskaitė Rasa Sabaliauskaitė Sonata Jarmalaitė 

机构地区：[1]Department of Oncogynecology,National Cancer Institute,Vilnius 08406,Lithuania [2]Institute of Biosciences,Vilnius University,Vilnius 10222,Lithuania [3]Laboratory of Clinical Oncology,National Cancer Institute,Vilnius 08406,Lithuania [4]National Center of Pathology,Affiliate of Vilnius University Hospital Santaros Klinikos,Vilnius 08406,Lithuania [5]Laboratory of Genetic Diagnostic,National Cancer Institute,Vilnius 08406,Lithuania

出　　处：《World Journal of Clinical Cases》2023年第18期4341-4349,共9页世界临床病例杂志

摘　　要：BACKGROUND Synchronous endometrial and ovarian cancer(SEOC)is a rare genital tract tumor.Precise diagnosis is crucial for the disease management since prognosis and overall survival differ substantially between metastatic endometrial cancer(EC)or OC.In this review we present 2 cases of women who were diagnosed with SEOC,and discuss the clinical characteristic of SEOC,diagnostic and molecular profiling issues.Next generation sequencing of 10 gene panel was performed on cancerous tissue and uterine lavage samples.CASE SUMMARY In our report patients with SEOC had endometroid type histology with early stage and low-grade histology for both EC and OC.They underwent surgical treatment and staging.Next-generation sequencing of 10 gene-panel identified CTNNB1,PIK3CA,and PTEN gene mutations in ovarian tissue in one case,while none of these genes were mutated in other case.Literature review in support to our data suggest a good prognosis for SEOC diagnosed at early stage.CONCLUSION Accurate diagnosis of SEOC is essential for disease management and gene mutation analysis can be helpful as a complementary diagnostic and prognostic tool.

关 键 词：Ovarian cancer Endometrial cancer Synchronous primary cancer Uterine lavage Case report 

分 类 号：R737.33[医药卫生—肿瘤] R737.31[医药卫生—临床医学]