肺癌患者血清CEA、NSE、CYFRA211、PLT与凝血功能指标的变化及意义  

Changes and Significance of Serum CEA,NSE,CYFRA211,PLT and Coagulation Function Indexes in Patients with Lung Cancer

作　　者：王慧[1] 俞善春 刘从瑶 陈永红 WANG Hui;YU Shanchun;LIU Congyao;CHEN Yonghong(Department of Laboratory,Xuancheng People's Hospital Xuancheng Hospital Affiliated to Wannan Medical College,Xuancheng,Anhui 242000,China)

机构地区：[1]宣城市人民医院皖南医学院附属宣城医院检验科,安徽宣城242000

出　　处：《转化医学杂志》2023年第3期143-146,共4页Translational Medicine Journal

基　　金：安徽省自然科学基金项目(1908085QH2153)。

摘　　要：目的探究肺癌患者血清癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA211)、血小板计数(PLT)与凝血功能指标的变化及临床意义。方法选取2019年3月—2022年5月收治的110例肺癌作为试验组,另选取同期收治的112例肺良性疾病患者作为对照组。比较2组血清CEA、NSE、CYFRA211、PLT、国际标准化比值(INR)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)及D-二聚体(D-D)水平,统计6个月后肺癌患者预后情况,采用多因素Logistic回归分析影响肺癌患者预后的危险因素。结果试验组CEA、NSE、CYFRA211、PLT、INR及D-D水平均高于对照组,PT、APTT水平低于对照组(P<0.01)。多因素Logistic回归分析结果显示,病理分期Ⅲ~Ⅳ期及CEA、NSE、CYFRA211、PLT、INR、PT、APTT、D-D水平异常是影响肺癌患者预后的独立危险因素(P<0.05,P<0.01)。结论CEA、NSE、CYFRA211、血小板参数及凝血功能指标可用于评估肺癌患者病情严重程度,是影响肺癌患者预后的独立危险因素,临床医师可根据其水平采取合理的治疗措施。Objective To investigate the changes of serum carcinoembryonic antigen(CEA),neuron-specific enolase(NSE),cytokeratin 19 fragment(CYFRA211),platelet count(PLT)and coagulation function indexes in patients with lung cancer and their clinical significance.Methods A total of 110 patients with lung cancer admitted from March 2019 to May 2022 were selected as the experimental group,and 112 patients with benign lung disease admitted during the same period were selected as the control group.Serum CEA,NSE,CYFRA211,PLT,international normalized ratio(INR),prothrombin time(PT),activated partial thrombin time(APTT)and D-dimer(D-D)levels of the two groups were compared,and the prognosis of lung cancer patients after 6 months was analyzed.Multivariate Logistic regression was used to analyze the risk factors affecting the prognosis of patients with lung cancer.Results The CEA,NSE,CYFRA211,PLT,INR and D-D levels in experimental groups were higher than those in control group,while the PT and APTT levels were lower than those in control group(P<0.01).Multivariate Logistic regression analysis showed that pathological stageⅢ-Ⅳ,CEA,NSE,CYFRA211,PLT,INR,PT,APTT and D-D levels were independent risk factors for the prognosis of patients with lung cancer(P<0.05,P<0.01).Conclusion CEA,NSE,CYFRA211,platelet parameters and the level of coagulation function can be used as indicators to evaluate the severity of lung cancer patients,and are independent risk factors affecting the prognosis of patients with lung cancer.Clinicians can take reasonable treatment measures according to the level of indicators.

关 键 词：肺肿瘤 癌胚抗原 神经元特异性烯醇化酶 血小板计数 国际标准化比 凝血酶原时间 预后 影响因素分析 

分 类 号：R734.2[医药卫生—肿瘤]