DCE-MRI定量参数对宫颈癌患者预后的预测价值  

Predictive Value of DCE-MRI Quantitative Parameters for the Prognosis of Cervical Cancer Patients

作　　者：耿欣 高跃丽 张静亚 耿飞龙 康非 王亚凡[3] 周立飞[3] GENG Xin;GAO Yueli;ZHANG Jingya;GENG Feilong;KANG Fei;WANG Yafan;ZHOU Lifei(Department of Obstetrics and Gynecology,Hebei Yiling Hospital,Shijiazhuang 050000,China;Department of Medical Imaging,Shijiazhuang Maternal and Child Health Hospital,Shijiazhuang 050051,China;Department of Obstetrics and Gynecology,Shijiazhuang Maternal and Child Health Hospital,Shijiazhuang 050051,China;Department of Medical Imaging,Shijiazhuang Ping'an Hospital,Shijiazhuang 050021,China)

机构地区：[1]河北以岭医院妇产科,石家庄050000 [2]石家庄市妇幼保健院医学影像科,石家庄050051 [3]石家庄市妇幼保健院妇产科,石家庄050051 [4]石家庄平安医院医学影像科,石家庄050021

出　　处：《转化医学杂志》2023年第3期162-166,共5页Translational Medicine Journal

基　　金：2021年石家庄市科学技术研究与发展自筹计划(211461013)。

摘　　要：目的探究动态增强磁共振成像(DCE-MRI)定量参数对宫颈癌患者复发危险度及3年生存率的影响。方法将2019年4月—2022年4月收治的宫颈癌100例作为观察组,另选取同期体检宫颈正常女性作为对照组,均行DCE-MRI检查,比较2组DCE-MRI定量参数,比较肿瘤复发与未复发患者临床特征及DCE-MRI定量参数,评价DCE-MRI定量参数对宫颈癌患者肿瘤复发的预测价值,比较不同水平DCE-MRI定量参数患者3年生存情况。结果观察组容积运转常数(K^(trans))、速率常数(K_(ep))、血管外细胞外间隙容积比(V_(e))高于对照组(P<0.01);肿瘤复发患者K^(trans)、K_(ep)、V_(e)高于未复发患者(P<0.01)。K^(trans)、K_(ep)、V_(e)联合预测宫颈癌患者肿瘤复发的曲线下面积(0.932)最大。宫颈癌患者K^(trans)、K_(ep)、V_(e)为高水平时,复发风险是低水平患者的2.250、2.432、1.995倍(P<0.05)。K^(trans)、K_(ep)、V_(e)高水平宫颈癌患者3年内生存率分别低于K^(trans)、K_(ep)、V_(e)低水平患者(P<0.05)。结论DCE-MRI定量参数与宫颈癌患者肿瘤复发危险度及3年生存率有关。Objective To investigate the impact of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)quantitative parameters on the recurrence risk and 3-year survival rate of cervical cancer patients.Methods One hundred patients with cervical cancer admitted from April 2019 to April 2022 were selected as the observation group,and healthy women undergoing cervical examination during the same period were selected as the control group,all of whom underwent DCE-MRI examination.The quantitative parameters of DCE-MRI were compared between the two groups,and the clinical characteristics and quantitative parameters of DCE-MRI between patients with and without tumor recurrence were compared.The predictive value of DCE-MRI quantitative parameters for tumor recurrence in cervical cancer patients was evaluated,and the 3-year survival of patients with different levels of DCE-MRI quantitative parameters was compared.Results The transfer rate constant(K^(trans)),rate constant(K_(ep)),and volume fraction of extravascular extracellular space(V_(e))of the observation group were higher than those of the control group(P<0.01).The K^(trans),K_(ep),and V_(e)of DCE-MRI in patients with tumor recurrence were higher than those in patients without recurrence(P<0.01).The area under the Receiver Operating Characteristic(ROC)curve(AUC)of K^(trans),K_(ep),and V_(e)was the highest for predicting tumor recurrence in cervical cancer patients.The recurrence risk of cervical cancer patients with high levels of K^(trans),K_(ep),and V_(e)was 2.250,2.432,and 1.995 times higher than that in patients with low levels(P<0.05).The 3-year survival rates of the high-level K^(trans),K_(ep),and V_(e)groups were lower than those of the low-level K^(trans),K_(ep),and V_(e)groups,respectively(P<0.05).Conclusion The quantitative parameters of DCE-MRI in cervical cancer patients are associated with the risk of tumor recurrence and 3-year survival rate.

关 键 词：宫颈肿瘤 动态增强磁共振成像 容积运转常数 速率常数 血管细胞外间隙容积比 受试者工作特征曲线 肿瘤复发 生存 

分 类 号：R737.33[医药卫生—肿瘤]