GLUT-1在梗阻性结肠癌支架植入术后的表达及临床意义  

Expression of GLUT-1 in obstructive colon cancer after stent implantation and its clinical significance

作　　者：张坤宁[1] 翟志伟[2] 刘小燕 金木兰[1] ZHANG Kun-ning;ZHAI Zhi-wei;LIU Xiao-yan;JIN Mu-lan(Department of Pathology,Beijing Chaoyang Hospital,Capital Medical University,Beijinɡ100020,China;Department of General Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijinɡ100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院病理科,北京100020 [2]首都医科大学附属北京朝阳医院普外科,北京100020

出　　处：《诊断病理学杂志》2023年第4期318-322,共5页Chinese Journal of Diagnostic Pathology

基　　金：国家自然科学基金青年科学基金(82203545)。

摘　　要：目的探讨梗阻性结肠癌支架植入术后肿瘤组织中葡萄糖转运蛋白1(GLUT-1)的表达与临床病理特征及无病生存(DFS)和预后的关系。方法收集我院2011—2020年梗阻性结肠癌行支架植入术后且临床资料完整的病例60例。运用免疫组化方法检测GLUT-1在肿瘤组织中的表达,分析其与临床病理特征之间的关系及生存预后的相关性。结果GLUT-1阳性表达率为86.7%,免疫组化评分为0分8例(13.3%),1分7例(11.7%),2分26例(43.3%),3分19例(31.7%)。Kaplan-Meier生存分析显示,GLUT-1表达0分的患者3年DFS为100%,GLUT-1表达1分的患者3年DFS为85.7%,GLUT-1表达2分的患者3年DFS为80.8%,GLUT-1表达3分的患者3年DFS为42.1%。表达3分的患者DFS低于0~2分的患者,差异有统计学意义(P=0.005)。Cox分析显示GLUT-1表达是患者独立的预后危险因素(P=0.001)。结论梗阻性结肠癌支架植入术后GLUT-1的高表达与患者预后相关,可以作为患者术后加强辅助治疗以及密切随访的有效依据。Objective To investigate the relationship between GLUT-1 expression and clinicopathologic features and prognosis in patients with obstructive colon cancer after stent implantation.Methods A total of 60 patients with obstructive colon cancer underwent stenting in our hospital from 2011 to 2020 were collected.Immunohistochemistry was used to detect GLUT-1 expression in tumor tissues,and the correlation between GLUT-1 expression and clinicopathologic features and prognosis was analyzed.Results GLUT-1 positive expression rate was 86.7%,and immunohistochemical scores were 0 in 8 cases(13.3%),1 in 7 cases(11.7%),2 in 26 cases(43.3%),and 3 in 19 cases(31.7%).Kaplan-Meier survival analysis showed that 3-year DFS of patients with GLUT-1 expression score 0 was 100%,3-year DFS of patients with GLUT-1 expression score 1 was 85.7%,3-year DFS of patients with GLUT-1 expression score 2 was 80.8%,and 3-year DFS of patients with GLUT-1 expression score 3 was 42.1%.The DFS of patients with score 3 was lower than that of patients with scores 0-2,and the difference was statistically significant(P=0.005).Cox analysis showed that GLUT-1 expression was an independent prognostic risk factor for patients(P=0.001).Conclusion GLUT-1 overexpression after stenting in obstructive left colon cancer is correlated with the prognosis of patients,which can be used as an effective basis for intensive adjuvant therapy and close follow-up.

关 键 词：结肠癌 肠梗阻 葡萄糖转运蛋白1 预后 

分 类 号：R735.3[医药卫生—肿瘤]