Positively charged patches:tonic for CAR ftness  

作　　者：Meraj H.Khan Jan Joseph Melenhorst 

机构地区：[1]Cell Therapy&Immuno-Engineering Program,Center for Immuno Therapy&Precision Immuno-Oncology,Lerner Research Institute,Cleveland Clinic Cleveland,OH,USA

出　　处：《Cell Research》2023年第5期331-332,共2页细胞研究（英文版）

摘　　要：Tonic signaling is a constitutive low-level activation of chimeric antigen receptors(CARs)in the absence of tumor antigen and plays an imperative role in the CAR-T efficacy.In a recent paper published in Cell Research,Chen et al.show that the positively charged patches on the surface of the CAR antigen-binding domain regulate CAR tonic signaling and open a door to further optimization of improvements of CAR.

关 键 词：CAR efficacy. 

分 类 号：R730[医药卫生—肿瘤]