重复经颅磁刺激配合丁苯酞软胶囊治疗帕金森合并认知功能障碍患者的效果  

Effect of repetitive transcranial magnetic stimulation combined with Butylphthalide Soft Capsules in the treatment of Parkinson′s disease with cognitive impairment

作　　者：胡晓颖 雷鸿雁 马珊珊 张薇 张彤 王瑞萍 HU Xiaoying;LEI Hongyan;MA Shanshan;ZHANG Wei;ZHANG Tong;WANG Ruiping(Department of Neurology,Liaoning Jinqiu Hospital,Liaoning Province,Shenyang110000,China)

机构地区：[1]辽宁省金秋医院神经内科,辽宁沈阳110000

出　　处：《中国当代医药》2023年第20期46-49,共4页China Modern Medicine

基　　金：辽宁省科学技术计划项目(2018225072)。

摘　　要：目的探究重复经颅磁刺激配合丁苯酞软胶囊治疗帕金森合并认知功能障碍患者的效果。方法选取2019年7月至2022年8月辽宁省金秋医院收治的100例帕金森合并认知功能障碍患者,按照随机数字表法分为研究组(50例)和对照组(50例),对照组使用丁苯酞软胶囊治疗,研究组在对照组的基础上加用重复经颅磁刺激,比较两组的临床疗效。结果治疗后,研究组的蒙特利尔认知评估量表(MoCA)和Barthel指数评价表(BI)评分均高于对照组,美国国立卫生研究院卒中量表(NIHSS)与改良Rankin量表(MRS)评分低于对照组,差异有统计学意义(P<0.05)。结论重复经颅磁刺激配合丁苯酞软胶囊在帕金森合并认知功能障碍患者早期康复治疗中的效果较好,能够显著促进神经系统与认知功能的恢复,并改善临床症状和预后表现,具有良好的临床应用价值。Objective To explore the effect of repetitive transcranial magnetic stimulation combined with Butylphthalide Soft Capsules in the treatment of Parkinson's disease with cognitive impairment.Methods A total of 100 patients with Parkinson's disease combined with cognitive dysfunction admitted to Liaoning Jinqiu Hospital from July 2019 to August 2022 were selected and divided into study group(50 cases)and control group(50 cases)according to random number table method.The control group was treated with Butylphthalide Soft Capsules,and the study group was treated with repetitive transcranial magnetic stimulation on the basis of the control group.The clinical efficacy of the two groups was compared.Results After treatment,the Montreal cognitive assessment(MoCA)and Brathel index(BI)scores of the study group were higher than those of the control group,and the National Institutes of Health stroke scales(NIHSS)and modified Rankin scale(MRS)scores were lower than those of the control group,with statistically significant differences(P<0.05).Conclusion Repetitive transcranial magnetic stimulation combined with Butylphthalide Soft Capsules has a good effect on the early rehabilitation of patients with Parkinson's disease complicated with cognitive dysfunction,which can significantly promote the recovery of nervous system and cognitive function,and improve clinical symptoms and prognosis.It has good clinical application value.

关 键 词：重复经颅磁刺激 丁苯酞软胶囊 帕金森 认知功能障碍 

分 类 号：R741[医药卫生—神经病学与精神病学]