血乳酸、CCSP、IL-22R在小儿肺炎中的表达及临床意义  

Expression and clinical significance of blood lactic acid,CCSP and IL-22R in children with pneumonia

作　　者：文勃[1] 李玲[2] 冯杨 罗丽 WEN Bo;LI Ling;FENG Yang;LUO Li(Department of Pediatric Respiratory Medicine,Ya′an People′s Hospital,Sichuan Province,Ya′an 625000,China;Department of Laboratory Medicine,Ya′an People′s Hospital,Sichuan Province,Ya′an 625000,China)

机构地区：[1]四川省雅安市人民医院呼吸儿科 [2]四川省雅安市人民医院检验科

出　　处：《河北医科大学学报》2023年第7期840-843,865,共5页Journal of Hebei Medical University

基　　金：四川省卫生健康委员会科研课题(20PJ156)。

摘　　要：目的探讨血乳酸、Clara细胞分泌蛋白(Clara cell secretory protein,CCSP)、白细胞介素22受体(interleukin-22 receptor,IL-22R)在小儿肺炎中的表达及临床意义。方法选取我院收治的150例肺炎患儿作为观察组,按病程分为急性期96例和恢复期54例,按照疾病严重程度分为轻症组和重症组,另选取同期80例健康儿童作为对照组,比较对照组、急性期、恢复期患儿血乳酸、CCSP、IL-22R水平,比较急性期与恢复期不同病情患儿血乳酸、CCSP、IL-22R水平,分析肺炎患儿血乳酸、CCSP、IL-22R水平之间的相关性,分析血乳酸、CCSP、IL-22R单独及联合检测诊断肺炎的价值并绘制ROC曲线图。结果对照组血乳酸和IL-22R低于急性期组和恢复期组,恢复期组低于急性期组(P<0.05);对照组CCSP高于急性期组和恢复期组,恢复期组高于急性期组(P<0.05);急性期组中,重症组A血乳酸和IL-22R水平高于轻症组A,CCSP低于轻症组A(P<0.05);恢复期组中,重症组B血乳酸和IL-22R水平高于轻症组B,CCSP低于轻症组B(P<0.05);Pearson相关性分析结果显示,急性期肺炎患儿血乳酸、IL-22R与CCSP呈负相关(r=-0.75、-0.81,P<0.05),血乳酸与IL-22R呈正相关(r=0.06,P<0.05);恢复期患儿血乳酸、CCSP、IL-22R之间无相关性(P>0.05);血乳酸、CCSP、IL-22R联合诊断小儿肺炎的AUC高于单项检测(P<0.05)。结论血乳酸和IL-22R在小儿肺炎中呈高表达,CCSP呈低表达,其水平异常可提示重症肺炎,血乳酸、CCSP、IL-22R联合检测对小儿肺炎的诊断具有较高价值。Objective To investigate the expression and clinical significance of blood lactic acid,Clara cell secretory protein(CCSP)and interleukin-22 receptor(IL-22R)in children with pneumonia.Methods A total of 150 children with pneumonia treated in our hospital were selected as the observation group.They were divided into 96 cases in the acute phase and 54 cases in the convalescent phase according to the course of disease,and were divided into mild disease group and severe disease group according to the severity of the disease.Another 80 healthy children during the same period were selected as the control group.The levels of blood lactic acid,CCSP,and IL-22R in the control group,acute phase and convalescent phase were compared,and these levels in children with different conditions in the acute phase and convalescent phase were compared.The correlation between the levels of blood lactic acid,CCSP and IL-22R in children with pneumonia and the value of blood lactic acid,CCSP and IL-22R alone and in combination in the diagnosis of pneumonia were analyzed,and the receiver operating characteristic(ROC)curve was drawn.Results Blood lactic acid and IL-22R in the control group were lower than those in the acute and convalescent phase groups,and lower in the convalescent group than in the acute group(P<0.05).CCSP in the control group was higher than that in the acute and convalescent groups,and higher in the convalescent group than in the acute group(P<0.05).In the acute phase group,the levels of blood lactic acid and IL-22R in severe group A were higher than those in mild group A,while CCSP was lower than that in mild group A(P<0.05).In the convalescent group,the levels of blood lactic acid and IL-22R in severe group B were higher than those in mild group B,while CCSP was lower than that in mild group B(P<0.05).Pearson correlation analysis showed that blood lactic acid and IL-22R were negatively correlated with CCSP in children with acute pneumonia(r=-0.75,0.81,P<0.05),and blood lactic acid was positively correlated with IL-22R(r

关 键 词：肺炎 乳酸 CLARA细胞分泌蛋白 IL-22受体 

分 类 号：R563.1[医药卫生—呼吸系统]