常规西药、益胃活血汤剂联合荜铃胃痛颗粒治疗HP相关性胃炎的疗效  

The effect of conventional western medicine,Yiwei Huoxue Decoction combined with Biling Weitong Granules on the treatment of HP related gastritis

作　　者：刘倩[1] 苏卫仙 杜丙杰 高振伟 何娣 赵俊精[1] 刘永香[2] LIU Qian;SU Weixian;DU Bingjie;GAO Zhenwei;HE Di;ZHAO JunJing;LIU Yongxiang(Department of Gastroenterology,Langfang People's Hospital,Langfang 065000,Hebei,China;Department of Traditional Chinese Medicine and Acupuncture,Langfang People's Hospital,Langfang 065000,Hebei,China)

机构地区：[1]廊坊市人民医院消化科,河北廊坊065000 [2]廊坊市人民医院中医针灸科,河北廊坊065000

出　　处：《西部医学》2023年第7期1001-1005,共5页Medical Journal of West China

基　　金：2022年度河北省医学科学研究课题计划(20221596)。

摘　　要：目的 探讨常规西药、益胃活血汤剂联合荜铃胃痛颗粒治疗幽门螺杆菌(HP)相关性胃炎的效果。方法 选取2021年6月—2022年12月廊坊市人民医院消化内科诊治的气滞血瘀型HP相关性胃炎患者200例,采用随机数字表法将其分为联合组、中药颗粒组、中药汤剂组及西药组,每组50例。西药组患者采用临床常规西药治疗,中药颗粒组在西药组基础上应用荜铃胃痛颗粒治疗,中药汤剂组在西药组基础上应用传统益胃活血汤剂治疗,联合组患者在西药组基础上加用荜铃胃痛颗粒与传统益胃活血汤剂治疗。比较各组症状缓解时间、临床疗效、胃镜下胃黏膜病变积分、T淋巴细胞亚群水平、HP根除率及用药安全性。结果 与西药组相比,联合组疗效及HP根除率更高,用药不良反应更少(P<0.05)。与西药组、中药颗粒组、中药汤剂组相比,联合组各症状缓解时间均更短,且中药颗粒组、中药汤剂组短于西药组(P<0.05)。治疗后,4组CD3、CD4、CD4/CD8水平较治疗前上升,CD8水平较治疗前下降,联合组CD3、CD4、CD4/CD8治疗后水平高于其他3组治疗后,胃镜下胃黏膜病变积分及CD8水平低于其他3组治疗后(P<0.05)。结论 常规西药、益胃活血汤剂联合荜铃胃痛颗粒用于气滞血瘀型HP相关性胃炎治疗中,其疗效优于三种药物单一应用,患者症状缓解时间明显缩短,HP根治术显著提升,患者免疫功能有效改善,且用药安全性高。Objective To explore the effect of conventional western medicine,Yiwei Huoxue Decoction combined with Diling Weitong Granules on HP associated gastritis.Methods A total of 200 patients with HP-related gastritis of Qi-stagnation and blood-stasis type diagnosed and treated by the Department of Gastroenterology in Langfang People's Hospital from June 2021 to December 2022 were gathered.They were divided into combination group,traditional Chinese medicine decoction group,traditional Chinese medicine granule group,and western medicine group using random number table method,with 50 patients in each group.The western medicine group was treated with conventional clinical western medicine,the Chinese medicine granule group was treated with cubeb granule on the basis of western medicine group,the Chinese medicine decoction group was treated with traditional Yiwei Huoxue decoction on the basis of western medicine group,and the combined group was treated with cubeb granule and traditional Yiwei Huoxue decoction on the basis of western medicine group.The symptom relief time,clinical efficacy,gastric mucosal lesion score under gastroscopy,T lymphocyte subgroup level,HP eradication rate and medication safety were compared among the four groups.Results Compared with western medicine group,combined group had higher efficacy and HP eradication rate,and fewer adverse drug reactions(P<0.05).Compared with the western medicine group,the Chinese medicine granule group,the Chinese medicine decoction group,the combined group had shorter symptom relief time,and the Chinese medicine granule group,the Chinese medicine decoction group was shorter than the Western medicine group(P<0.05).After treatment,the levels of CD3,CD4 and CD4/CD8 in the four groups increased and CD8 decreased compared with those before treatment.The levels of CD3,CD4 and CD4/CD8 in the combined group after treatment were higher than those in the other three groups,and the scores of gastric mucosal lesions and CD8 levels under gastroscopy were lower than those in the oth

关 键 词：幽门螺杆菌 胃炎 气滞血瘀型 荜铃胃痛颗粒 益胃活血汤 T淋巴细胞亚群 

分 类 号：R573.3[医药卫生—消化系统]