Klinefelter综合征的生育问题:策略与时机  

Fertility of Klinefelter syndrome: strategy and opportunity

作　　者：黄文彬 何志伟 胡欣[1] 陈国芳[1] 刘超[1] Huang Wenbin;He Zhiwei;Hu Xin;Chen Guofang;Liu Chao(Department of Endocrinology,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210028,China;Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学附属中西医结合医院内分泌科,南京210028 [2]南京中医药大学,南京210023

出　　处：《国际内分泌代谢杂志》2023年第3期207-210,共4页International Journal of Endocrinology and Metabolism

摘　　要：Klinefelter综合征(KS)是男性不育中最常见的性染色体异常疾病, 不同年龄阶段的KS患者临床表现程度不一。在治疗方面, 除了睾酮替代外, 患者的生育问题愈加受到重视, 但如何保留KS患者的生育功能仍是临床诊疗中面临的挑战。随着辅助生殖技术的发展与成熟, KS患者的生育机会显著提升。通过对KS不育的发病机制、影响因素、筛查评估、治疗与KS患者子代筛查等方面进行详细探讨, 可为KS患者的生育管理提供更加科学而合理的个体化方案。Klinefelter syndrome(KS)is the most common sex chromosomal abnormality in males with infertility,and the degree of clinical manifestations in KS patients varies with different ages.In terms of treatment,in addition to testosterone replacement,the fertility problem of patients is getting more and more attention,but how to preserve the reproductive function of KS patients is still a challenge in clinical.The advancement and implication of assisted reproductive technology have significantly improved fertility opportunities in KS patients in recent years.A comprehensive understanding of the pathogenesis of infertility contributing factors,evaluation,treatment,and offspring screening in patients with KS can provide a standardized and individualized protocol regarding fertility management.

关 键 词：KLINEFELTER综合征 生育 精子保存 评估 诊疗 

分 类 号：R698.2[医药卫生—泌尿科学]