Decoy Nanozymes Enable Multitarget Blockade of Proinflammatory Cascades for the Treatment of Multi-Drug- Resistant Bacterial Sepsis  

作　　者：Xuancheng Du Mingzhen Zhang Huiting Zhou Weijie Wang Chengmei Zhang Lei Zhang Yuanyuan Qu Weifeng Li Xiangdong Liu Mingwen Zhao Kangsheng Tu Yong-Qiang Li 

机构地区：[1]Institute of Advanced Interdisciplinary Science,School of Physics,Shandong University,Jinan 250100,China [2]School of Basic Medical Sciences,Xi'an Key Laboratory of Immune Related Diseases,Xi'an Jiaotong University,Xian 710061,China [3]Institute of Pediatric Research,Children's Hospital of Soochow University,Suzhou 215025,China [4]Laboratory Animal Center of Shandong University,Jinan 250012,China [5]Department of Critical Care Medicine,the First Afliated Hospitalof Xi'an Jiaotong University,Xi'an 70061,China [6]Dpartment of Hepatobiliary Surgery,the First liated HospitalofXian JiaotongUniversty,Xian 00,China [7]Suzhou Research Institute,Shandong University,Suzhou 215123,China [8]College of Chemistry,Chemical Engineering and Materials Science,Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals,Shandong Normal University,Jinan 250014,China

出　　处：《Research》2023年第2期187-201,共15页研究（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(31500802,82172132,and 82000523);the Natural Science Foundation of Jiangsu Province(BK20190097 and BK20190053);the Program of Qilu Young Scholars of Shandong University;This work was also supported by the Cyrus Tang Foundation,the Taishan Scholars Program for Young Expert of Shandong Province(tsqn201909021);the Youth Cross-Scientific Innovation Group of Shandong University.

摘　　要：Sepsis is a life-threatening organ dysfunction characterized by severe systemic inflammatory response to infection.Effective treatment of bacterial sepsis remains a paramount clinical challenge,due to its astonishingly rapid progression and the prevalence of bacterial drug resistance.

关 键 词：SEPSIS clinical PREVALENCE 

分 类 号：R515.3[医药卫生—内科学]