FOXO3在脑缺血中的作用  

The Role of FOXO3 in Cerebral Ischemia

作　　者：储晓娇 王锦坤 章帆 尚文豆 刘苏亚 何治[1,2] CHU Xiaojiao;WANG Jinkun;ZHANG Fan;SHANG Wendou;LIU Suya;HE Zhi(Third Grade Pharmacological Laboratory on Traditional Chinese Medicine,State Administration of Traditional Chinese Medicine,China Three Gorges University,Yichang 443002,China;Basic Medical Science,China Three Gorges University,Yichang 443002,China)

机构地区：[1]三峡大学国家中医药管理局中药药理科研三级实验室,宜昌443002 [2]三峡大学基础医学院,宜昌443002

出　　处：《中国细胞生物学学报》2023年第5期795-801,共7页Chinese Journal of Cell Biology

基　　金：湖北省卫健委联合基金重点项目(批准号:WJ2019H526);天然产物研究与利用湖北省重点实验室开放基金(批准号:NPRD-2018001);国家自然科学基金(批准号:82073824)资助的课题。

摘　　要：脑缺血是导致死亡和长期残疾的主要原因,是一个全球性的健康问题,其病因复杂,发病机制尚不明确。转录因子叉头盒蛋白O3(Forkhead box protein O3, FOXO3)经翻译后修饰(posttranslational modifications, PTMs)后,自身活性发生改变,通过对靶基因的调控,参与调节脑缺血后的凋亡、炎症、氧化应激、自噬及血脑屏障损伤。值得注意的是, FOXO3对缺血性脑损伤不但有促进作用,还具有保护作用。该文就FOXO3的结构及翻译后修饰进行简单介绍,阐述其在脑缺血中的作用,旨在为该疾病的研究提供新思路。Cerebral ischemia is a major cause of death and long-term disability,which is a global health problem with complex etiology and unclear pathogenesis.The transcriptional factor FOXO3(Forkhead box protein O3)changes its activity after PTMs(post-translation modifications),and it is involved in the regulation of apoptosis,inflammation,oxidative stress,autophagy and blood-brain barrier after cerebral ischemia through the regulations of target genes.It is noteworthy that FOXO3 not only promotes but also protects ischemic brain injury.In this paper,the structure and post-translational modification of FOXO3 are briefly introduced,and its role in cerebral ischemia is expounded,in order to provide new ideas for the study of this disease.

关 键 词：FOXO3 脑缺血 翻译后修饰 

分 类 号：R743.3[医药卫生—神经病学与精神病学]