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作 者:李洋洋 邝卫红 LI Yang-Yang;KUANG Wei-Hong(The First Clinical Medical School,Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;Guangdong Medical University,Dongguan 523000 Guangdong,China)
机构地区:[1]广州中医药大学第一临床医学院,广东广州510405 [2]广东医科大学,广东东莞523000
出 处:《广州中医药大学学报》2023年第7期1825-1831,共7页Journal of Guangzhou University of Traditional Chinese Medicine
基 金:广东省中医药局科研课题(编号:20213011)。
摘 要:【目的】基于数据挖掘探讨岭南地区肝衰竭患者的用药规律。【方法】对中国知网、中国生物医学文献库、万方数据库等中文数据库中采用中药方剂治疗岭南地区肝衰竭患者的文献进行检索,建立岭南地区肝衰竭用药数据库。采用频数统计、关联规则分析、复杂网络分析方法探析岭南地区肝衰竭患者中药治疗的用药规律。【结果】共纳入合格文献58篇,涉及处方58首,中药142味。岭南地区肝衰竭治疗以清热凉血解毒药、利水渗湿药、益气健脾药、活血化瘀药为主,注重顾护中焦脾胃;其核心药物为茵陈、赤芍、大黄、栀子、白术、甘草、丹参、白花蛇舌草、茜草、郁金,常用药对为赤芍-茵陈、大黄-茵陈、栀子-茵陈;清热药与利水渗湿药常配伍使用。此外,常使用岭南地区道地药材白花蛇舌草、田基黄、鸡骨草、溪黄草等。【结论】岭南地区肝衰竭患者的中药治疗具有一定的地域特色,这与肝衰竭的病因病机及岭南地区多湿多热的特点密切相关。挖掘得到的用药规律可为岭南地区肝衰竭的中医治疗提供参考。Objective To investigate the medication rules of Chinese herbal medicine for the treatment of patients with liver failure in the Lingnan region based on data mining.Methods The literature on the treatment of patients with liver failure in Lingnan region with Chinese herbal prescriptions in Chinese databases such as CNKI,CBMdisc and Wanfang were retrieved,and then the database of medicines for liver failure in the Lingnan region was established.Frequency statistics,association rule analysis and complex network analysis were used to explore the medication rules of Chinese herbal medicine in the treatment of liver failure patients in Lingnan region.Results A total of 58 qualified articles were included,involving 58 prescriptions and 142 herbal medicines.For the treatment of liver failure in Lingnan,herbs for clearing heat,cooling blood and removing toxins,herbs for inducing diuresis and draining dampness,herbs for replenishing qi and invigorating spleen,and herbs for activating blood and removing blood stasis were frequently used,and the protection of spleen and stomach of the middle energizer was stressed.The core medicines for the treatment of liver failure in Lingnan were Artemisiae Scopariae Herba,Paeoniae Radix Rubra,Rhei Radix et Rhizoma,Gardeniae Fructus,Atractylodis Macrocephalae Rhizoma,Glycyrrhizae Radix et Rhizoma,Salviae Miltiorrhizae Radix et Rhizoma,Hedyotis Diffusae Herba,Rubiae Radix,and Curcumae Radix.The commonly-used drug pairs are Paeoniae Radix Rubra-Artemisiae Scopariae Herba,Rhei Radix et Rhizoma-Artemisiae Scopariae Herba,and Gardeniae Fructus-Artemisiae Scopariae Herba.The heat-clearing herbs were frequently used together with the herbs for inducing diuresis and draining dampness.In addition,the Lingnan genuine regional herbs of Hedyotis Diffusae Herba,Hyperici Japonici Herba,Abri Herba,and Serrate Rabdosia Herb were often used.Conclusion The treatment of liver failure patients in Lingnan exerts certain regional characteristics,which are closely related to the etiology and pathogenesis of li
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