血清sFsa、IL-17对急性淋巴细胞白血病化疗效果的预测价值  

Predictive value of serum sFas and IL-17 on chemotherapy effect of acute lymphoblastic leukemia

作　　者：雷小茹 戴进前[1] 任婧婧[1] 袁茂文 LEI Xiaoru;DAI Jinqian;REN Jingjing;YUAN Maowen(Department of Hematology,Xi′an Central Hospital/Xi′an Institute of Hematology,Xi′an,Shaanxi 710000,China)

机构地区：[1]西安市中心医院血液科/西安市血液病研究所,陕西西安710000

出　　处：《检验医学与临床》2023年第14期2023-2027,共5页Laboratory Medicine and Clinic

基　　金：2021西安市科技计划项目(21YXYJ0017)。

摘　　要：目的 分析血清可溶性跨膜蛋白(sFas)、白细胞介素(IL)-17对急性淋巴细胞白血病(ALL)患者化疗效果的预测价值。方法 选取2018年5月至2021年12月西安市中心医院收治的110例ALL患者作为研究对象,所有患者均实施常规化疗方案,共治疗4周,于治疗结束当天评估患者的化疗效果,根据化疗效果分为化疗无效组(20例)和化疗有效组(90例)。记录所有患者一般资料并检测入院第2天的血清sFas、IL-17等实验室指标水平,重点分析血清sFas、IL-17水平对ALL患者化疗效果的预测价值。结果 110例ALL患者治疗后有82例达到完全缓解,8例达到CR伴血细胞不完全恢复,总反应率为81.82%;化疗无效组血清sFas、IL-17水平均明显高于化疗有效组,差异均有统计学意义(P<0.05);多因素Logistic回归分析结果显示,血清sFas、IL-17水平与ALL患者化疗效果有关(P<0.05);受试者工作特征曲线分析结果显示,ALL患者入院第2天血清sFas、IL-17水平单项及联合检测对ALL患者化疗效果均具有一定预测价值,且以2项指标联合检测的预测价值更好。结论 血清sFas、IL-17水平检测可用于预测ALL患者的化疗效果,且2项指标联合检测预测的价值更好。Objective To analyze the predictive value of serum soluble transmembrane protein(sFas)and interleukin(IL)-17 on chemotherapy effect of acute lymphoblastic leukemia(ALL)in patients.Methods A total of 110 ALL patients admitted to Xi′an Central Hospital from May 2018 to December 2021 were selected as the study objects.All patients were treated with conventional chemotherapy regimen for a total of 4 weeks.The chemotherapy effect of patients was evaluated on the day after treatment,and they were divided into chemotherapy ineffective group(20 cases)and chemotherapy effective group(90 cases)according to chemotherapy effect.The general data of ALL patients were recorded and the serum sFas,IL-17 levels and other laboratory indicators on the second day of admission were detected,and the predictive value of serum sFas and IL-17 levels on the chemotherapy effect of ALL patients was analyzed.Results Among 110 ALL patients,82 achieved complete remission after treatment,8 achieved CR with incomplete blood cell recovery,and the overall response rate was 81.82%.The serum sFas and IL-17 levels in chemotherapy ineffective group were significantly higher than those in chemotherapy effective group,the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that serum sFas and IL-17 levels were related to the chemotherapy effect of ALL patients(P<0.05).The results of receiver operating characteristic curve analysis showed that serum sFas and IL-17 levels alone and in combination had certain predictive value for the efficacy of chemotherapy in ALL patients on the second day of admission,and the combined detection of the 2 indicators had a better predictive value.Conclusion Serum sFas and IL-17 levels can be used to predict the efficacy of chemotherapy in ALL patients,and the combined detection of the 2 indicators has a better predictive value.

关 键 词：急性淋巴细胞白血病 化疗效果 可溶性跨膜蛋白 白细胞介素-17 

分 类 号：R733.71[医药卫生—肿瘤]