基于TLR4/NF-κB信号通路及血清CXCL16、ACA评价依达拉奉右莰醇对ACI神经功能的保护作用  

Protective effect of Edaravone Dexbornol on neurological function in patients with acute cerebral infarction through TLR4/NF-k B signaling path signaling pathway and serum CXCL16,ACA

作　　者：朱学芳[1] 朱建建[1] 沈海清[1] Zhu Xuefang;Zhu Jianjian;Shen Haiqing(Department of Neurology,Rugao People's Hospital,Jiangsu 226500,China)

机构地区：[1]如皋市人民医院神经内科,江苏226500

出　　处：《脑与神经疾病杂志》2023年第7期401-406,共6页Journal of Brain and Nervous Diseases

摘　　要：目的基于Toll样受体(TLR)4/核因子κB(NF-κB)信号通路及血清CXC型趋化因子配体16(CXCL16)、抗心磷脂抗体(ACA)评价依达拉奉右莰醇治疗急性脑梗死(ACI)的疗效及神经功能保护作用。方法将102例ACI患者根据是否使用依达拉奉右莰醇分为两组:观察组(n=54)均在常规治疗基础上接受依达拉奉右莰醇治疗,对照组(n=48)未用依达拉奉治疗。对比两组治疗前及治疗7d、14d、30d后神经功能缺损量表(NIHSS),治疗前及治疗14d检测血清TLR4、NF-κB、白介素1β(IL-1β)、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)、CXCL16、ACA,随访3个月采用改良Rankin量表(mRS)评价预后。结果治疗后7d、14d、30d,两组NIHSS评分均下降,而观察组明显低于对照组(P<0.05)。治疗14d后,两组血清TLR4、NF-κB、IL-1β、IL-6、TNF-α、CXCL16、ACA水平均下降,且观察组明显低于对照组(P<0.05)。随访3个月,观察组mRS均分低于对照组(P<0.05),但两组预后差异无统计学意义(79.63%vs 68.75%,P>0.05)。结论依达拉奉右莰醇用于ACI的治疗可保护神经功能,其机制可能与调节TLR4/NF-κB信号通路及血清CXCL16、ACA表达有关。Objective To evaluate the protective effect of Edaravone Dexbornol on neurological function in patients with acute cerebral infarction(ACI)through Toll-like receptor(TLR)4/nuclear factor k B(NF-k B)signaling path signaling pathway and serum CXC chemokine ligand 16(CXCL16)and and anticardiolipin antibody(ACA).Methods 102 ACI patients were divided into two groups according to whether or not to use Edaravone Dexbornol:the observation group(n=54)received Edaravone Dexbornol treatment on the basis of conventional treatment,and the control group(n=48)did not use edaravone treatment.The score of National Institutes of Health Stroke Scale(NIHSS)was compared between the two groups before treatment and after 7d,14d and 30d after treatment.Serum TLR4,NFk B,interleukin 1β(IL-1β),interleukin 6(IL-6),tumor necrosis factor-α(TNF-α),CXCL16 and ACA were detected before treatment and 14d after treatment.All followed up for 3 months using the modified Rankin scale(mRS)to evaluate the prognosis.Results At 7d,14d,and 30d after treatment,the NIHSS scores of the two groups decreased,and the observation group was significantly lower than that of the control group(P<0.05).After 14 days of treatment,the levels of serum TLR4,NF-k B,IL-1β,IL-6,TNF-α,CXCL16 and ACA in the two groups decreased,and the observation group were significantly lower than the control group(P<0.05).After 3 months of follow-up,the average mRS of the observation group was lower than that of the control group(P<0.05),but there was no significant dfference in the good prognosis rate between the two groups(79.63%us 68.75%,P>0.05).Conclusion Edaravone Dexbornol can protect neurological function of ACI,and its mechanism may be related to the regulation of TLR4/NF-k B signaling pathway and the expression of serum CXCL16 and ACA.

关 键 词：急性脑梗死 依达拉奉右莰醇 Toll样受体4 核因子ΚB CXC型趋化因子配体16 抗心磷脂抗体 

分 类 号：R743.32[医药卫生—神经病学与精神病学]