胆囊收缩素调节吗啡成瘾研究进展  

The role of cholecystokinin in morphine addiction

作　　者：杨黎华[1] 殷勤红 白洁 YANG Li-hua;YIN Qin-hong;BAI Jie(Narcotics Control School,Yunnan Police College,Kunming 650223,China;Medical School,Kunming University of Science and Technology,Kunming 650500,China)

机构地区：[1]云南警官学院禁毒学院,昆明650223 [2]昆明理工大学医学院,昆明650500

出　　处：《中国药物依赖性杂志》2023年第3期185-189,共5页Chinese Journal of Drug Dependence

基　　金：国家自然科学基金-云南省联合基金重点项目(U2002220)。

摘　　要：内源性抗阿片肽类物质胆囊收缩素(cholecystokinin,CCK),广泛分布于中枢神经系统内,参与学习记忆、激素调节、痛觉、食欲等生理功能,并发挥着重要作用。吗啡成瘾会导致耐受、戒断并在中枢神经系统形成病理性记忆。CCK通过调节多巴胺神经递质和学习记忆等对吗啡成瘾具有调控作用。本文综述了近年来CCK系统在吗啡成瘾的研究进展,为阿片类成瘾的治疗提供新的思路。Cholecystokinin(CCK),an endogenous anti-opioid peptide,is widely distributed in the central nervous system and plays an important role in learning and memory,hormone regulation,pain perception,and appetite.Morphine addiction leads to tolerance,withdrawal and pathological memory formation in the central nervous system.CCK participates in the process of morphine addiction,tolerance,and withdrawal by regulating dopamine neurotransmitter and learning and memory.This paper reviews the research progress of CCK system in morphine addiction in recent years to provide new ideas for the treatment of opioid addiction targeting this peptide.

关 键 词：胆囊收缩素 吗啡成瘾 学习记忆 突触可塑性 耐受 戒断 

分 类 号：R749[医药卫生—神经病学与精神病学]