基于复杂网络分析专利文献中药戒毒用药规律  

Analysis of detoxification medication rules of traditional Chinese medicine in patent literature based on complexnetwor

作　　者：王建华[1] 刘建平[1] 樊蓉 鲁春丽 张健[4] 鞠宝兆[1,5] WANG Jian-hua;LIU Jian-ping;FAN Rong;LU Chun-li;ZHANG Jian;JYU Bao-zhao(College of Traditional Chinese Medicine in Liaoning University of Traditional Chinese Medicine,Shenyang l10847,China;Evidence-based Medicine Center of Bejing University of Traditional Chinese Medicine,Beijing 100029,China;Drug Clinical Trial Office of Shenyang Xingqi Eye Hospital,Shenyang I10057,China;Academic Affairs Office in Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China)

机构地区：[1]辽宁中医药大学中医学院,沈阳110847 [2]北京中医药大学循证医学中心,北京100029 [3]沈阳兴齐眼科医院药物临床试验办公室,沈阳110057 [4]辽宁中医药大学教务处,沈阳110847 [5]广东药科大学中医药研究院,广东510006

出　　处：《中国药物依赖性杂志》2023年第3期213-218,共6页Chinese Journal of Drug Dependence

基　　金：中央引导地方科技发展专项(2020JH6/10500004);辽宁省博士科研启动基金计划项目(2019-BS-162);辽宁省教育厅科学研究重点攻关项目(L202056);辽宁中医药大学人文社科重点项目(2021LNZYZD003)。

摘　　要：目的总结中药戒毒的处方用药规律,为科研和临床用药提供参考。方法检索世界传统药物专利数据库收录的2020年2月26日前公开的关于中药戒毒的专利文献。提取处方信息建立数据库,统计药物频次。应用复杂网络挖掘常用药对和核心方药。结果共得到357个戒毒中药处方,涉及1067味中药,累计5536用药频次。常用药有:甘草(160)、延胡索(134)、当归(129)、人参(107)、黄芪(102)、酸枣仁(86)、党参(80)、茯苓(76)、杜仲(73)、枸杞(66)。按功效归类,主要分为补虚药(1054)、活血化瘀药(264)、清热药(180)、平肝熄风药(150)、安神药(140)等。常用药对为:当归-甘草(77)、延胡索-甘草(75)、黄芪-甘草(68)、当归-黄芪(66)、延胡索-人参(58)等。核心处方药味包括:甘草、当归、黄芪、延胡索、酸枣仁、人参、党参、茯苓、杜仲、川芎、白术、白芍、枸杞、黄连、柴胡。结论中药戒毒用药以扶正为本,兼顾祛邪,甘草、延胡索、当归、人参等是最常用的药物。当归-甘草为最常用药对。核心处方包含甘草、当归、黄芪、延胡索等药物。Objective To summarize the prescription medication rules of Traditional Chinese medicine for detoxification,and provide reference for detoxification research and clinical medication.Methods Retrievedpatentliteratureon traditional Chinese medicine detoxification published before February 26,2020 in the World Traditional Medicine Patent Database.The prescription information of patent literature was extracted to establish a database,the frequency of drugs was counted,and the complex network analysis of drugs was carried out to mine common drug pairs and core prescriptions.Results A total of 357 prescriptions of traditional Chinese medicine for detoxification were sorted out,involving 1067 Chinese medicines,and the cumulative frequency of drug use was 5536.The top ten most frequently used drugs were:licorice(160),yanhusuo(134),angelica(129),ginseng(107),astragalus(102),sour jujube kernel(86),Codonopsis(80),Poria(76),Eucommia(73),wolfberry(66).According to the efficacy classification,traditional Chinese medicine were mainly classified as tonifying deficiency medicine(1054),promoting blood circulation and removing blood stasis medicine(264),clearing heat medicine(180),calming liver wind medicine(150),tranquilizers(140),etc.Through complex network analysis,common drug pairs were obtained as follows:Angelica-Clycyrrhiza(77),Corydalis-Glycyrrhiza(75),Astragalus-Glycyrrhiza(68),Angelica-Glycyrrhiza(66),Corydalis-Pengshen(58),etc.The core prescription included:Glycyrrhiza uralensis,Angelica sinensis,Astragalus membranaceus,Corydalis yanhusuo,

关 键 词：中药 戒毒 复杂网络 专利文献 用药规律 

分 类 号：R749[医药卫生—神经病学与精神病学]