血清抵抗素、丙二醛、IL-6联合检测对急性胰腺炎严重程度的预测价值  

Predictive value of a combiniton detection of serum resistin,malondialdehyde and IL-6 tests in predicting the severity of acute pancreatitis

作　　者：于雪华 张宁[2,3] 吴婧 孙惠[2] 赵云红 刘改芳 Yu Xuehua;Zhang Ning;Wu Jing;Sun Hui;Zhao Yunhong;Liu Gaifang(Graduate School of Hebei North University,Zhangjiakou 075132,China;Department of Gastroenterology,Hebei General Hospital,Shijiazhuang 050057,China;Graduate School of Hebei Medical University,Shijiazhuang 050017,China)

机构地区：[1]河北北方学院研究生院,河北张家口075132 [2]河北省人民医院消化内科,河北石家庄050057 [3]河北医科大学研究生院,河北石家庄050017

出　　处：《临床荟萃》2023年第5期412-416,共5页Clinical Focus

基　　金：河北省重点科技研究计划——重症胰腺炎第三种情况白细胞升高临床意义及机制(20200747)。

摘　　要：目的探讨联合检测血清脂肪因子抵抗素、脂质过氧化产物丙二醛和炎症因子白细胞介素6(Interleukin 6,IL-6)水平对急性胰腺炎(Acute pancreatitis,AP)严重程度的预测价值。方法选取2022年1月至2022年11月在河北省人民医院消化内科住院治疗的AP患者120例,将患者分为3组:轻症急性胰腺炎(Mild acute pancreatitis,MAP)组、中度重症急性胰腺炎(Moderate severe acute pancreatitis,MSAP)组、重症急性胰腺炎(Severe acute pancreatitis,SAP)组。收集患者一般资料,在患者发病48~72小时内抽取静脉血4ml,采用ELISA方法检测血清抵抗素、丙二醛、IL-6水平。结果3组血清抵抗素、丙二醛、IL-6水平差异有统计学意义(P<0.05)。抵抗素、丙二醛、IL-6三者间呈显著线性相关性(P<0.01)。血清抵抗素、丙二醛、IL-6预测SAP(MSAP+SAP)的ROC曲线下面积分别为0.850、0.774、0.817,敏感度和特异度分别为77.80%和78.80%;90.70%和62.10%;72.20%和83.30%。联合检测血清抵抗素、丙二醛、IL-6预测SAP(MSAP+SAP)的ROC曲线下面积为0.890,敏感度和特异度分别为74.10%和90.90%。结论SAP患者血清抵抗素、丙二醛、IL-6均明显升高,联合检测脂肪因子抵抗素、脂质过氧化物丙二醛、炎症因子IL-6评估AP严重程度具有较高的效能,或许可以成为预测AP严重程度的一种新方法。Objective To investigate the predictive value of a combination detection of serum resistin,malondialdehyde(MDA)and interleukine-6(IL-6)in predicting the severity of acute pancreatitis(AP).Methods A total of 120 AP patients hospitalized in the Department of Gastroenterology,Hebei General Hospital,from January 2022 to November 2022 were selected and divided into three groups:mild acute pancreatitis group(MAP),moderately severe acute pancreatitis(MSAP)and severe acute pancreatitis group(SAP).Baseline characteristics of them were collected,and 4 ml of venous blood was drawn within 48-72 hours of onset of illness to measure serum levels of resistin,MDA and IL-6 by enzyme-linked immunosorbent assay(ELISA).Results There were significant differences in serum resistin,MDA and IL-6 levels among the MAP,MSAP and SAP group(P<0.05).There was a significant linear correlation among serum resistin,MDA and IL-6 levels(P<0.01).The area under the receiver operating characteristic(ROC)curves(AUC)of detecting serum resistin,MDA and IL-6 in predicting SAP(including both MSAP and SAP)was 0.850,0.774 and 0.817,respectively,with the sensitivity of 77.80%,90.70%and 72.20%,respectively,and the specificity of 78.80%,62.10%and 83.30%,respectively.The AUC of a combination detection of them in predicting SAP(MSAP+SAP)was 0.890,with the sensitivity and specificity of 74.10%and 90.90%,respectively.Conclusion Serum resistin,MDA and IL-6 levels are significantly elevated in SAP patients,and their combination detection has a high efficacy in predicting the severity of AP,which may be used as a novel predictive method.

关 键 词：急性胰腺炎 脂肪组织 抵抗素 丙二醛 白细胞介素6 

分 类 号：R576[医药卫生—消化系统]