染色体畸变和微核分析在放射工作人员职业健康监护中的价值探讨  

Evaluation of the application value of chromosome aberration and micronucleus analysis in occupational health surveillance of radiation workers

作　　者：韩林 赵风玲 刘玉龙[2] 吕玉民 HAN Lin;ZHAO Fengling;LIU Yulong;LYU Yumin(The Third People’s Hospital of Henan Province(Henan Occupational Disease Hospital),Henan Key Laboratory of Medicine on Radiobiology and Epidemiology,Zhengzhou 450052;Second Affiliated Hospital of Soochou University,Jiangsu Suzhou 215004)

机构地区：[1]河南省第三人民医院(河南省职业病医院)河南省辐射生物与流行病学医学重点实验室,郑州450052 [2]苏州大学附属第二医院,江苏苏州215004

出　　处：《辐射防护》2023年第4期366-371,共6页Radiation Protection

基　　金：河南省医学科技攻关计划项目(LHGJ20190815);苏大附二院学科建设托举工程核技术医学应用创新团队项目(编号:XKTJ-HTD2021001)。

摘　　要：外周血淋巴细胞染色体畸变和微核作为对电离辐射较为敏感的生物指标,在国内外辐射生物剂量估算中得到广泛应用和认可,但在放射工作人员职业健康监护中的价值尚有值得讨论的问题。本文从染色体畸变和微核形成机制入手,探讨这2项细胞遗传指标在放射工作人员职业健康检查中的意义和实用价值,供同行讨论和参考。Application of chromosome aberration and micro-nucleus in peripheral blood lymphocyte as radio-sensitive biological indicators to biodosimetry was widely recognized by the international academia.Nevertheless some problems on the application value of the indicators are still worth discussing in occupational health surveillance of radiation workers.In this paper,based on the formation mechanism of chromosome aberration and micro-nucleus,the signification and practical value of the two indicators were explored in occupational medical examination of radiation workers,in order to provide discussion and a reference for the counterparts.

关 键 词：放射工作人员 职业健康监护 染色体畸变 微核 

分 类 号：TL75[核科学技术—辐射防护及环境保护]