地黄饮子定向透药治疗肾虚痰瘀型脑卒中后吞咽障碍患者的疗效及其对生存质量的影响  

The Effect of Targeted Drug Penetration of Dihuang Yinzi on the Efficacy and Quality of Life in Patients with Dysphagia after Stroke with Kidney Deficiency and Phlegm Stasis Type

作　　者：朱化珍 王萍 陈德兴[2] 杨化兰 ZHU Hua-zhen;WANG Ping;CHEN De-xing(Department of Traditional Chinese Medicine,Shanghai Pudong New Area Pulmonary Hospital,Shanghai 201209)

机构地区：[1]上海市浦东新区肺科医院中医科,上海201209 [2]上海中医药大学基础医学院,上海201203 [3]复旦大学浦东医学中心上海浦东医院神经内科,上海201399

出　　处：《医学临床研究》2023年第6期838-840,844,共4页Journal of Clinical Research

基　　金：上海市浦东新区卫生健康委员会卫生计生科研项目(PW2019A-23);上海市科技计划项目(20YF1443100)。

摘　　要：【目的】探讨中药复方地黄饮子定向透药治疗肾虚痰瘀型脑卒中后吞咽障碍患者的疗效及其对生存质量的影响。【方法】64例脑卒中后吞咽障碍患者随机分为两组,每组32例。对照组予以吞咽训练,观察组在吞咽训练的基础上给予地黄饮子定向透药治疗。比较两组患者的疗效,并以生活质量简表WHOQOL-BREF量表为评价工具评估两组患者的生存质量,观察两组患者生存质量总评分及4个领域评分的差异。【结果】观察组总有效率为84.38%(27/32),高于对照组的62.50%(20/32),差异有统计学意义(P<0.05),两组患者均未发生不良事件。治疗前,两组患者各项生存质量评分比较,差异均无统计学意义(均P>0.05);治疗后,两组患者各项生存质量评分均高于治疗前,且差异有统计学意义(P<0.05)。治疗后,观察组患者的生存质量总评分和环境、生理两个领域的评分均高于对照组(P<0.05);两组社会关系、心理两个领域的评分比较,差异无统计学意义(P>0.05)。【结论】地黄饮子定向透药联合吞咽训练可显著提高脑卒中后吞咽障碍患者的生存质量,且安全性良好。【Objective】To explore the effect of the Dihuang Yinzi(Rehmannia Decoction),a traditional Chinese medicine compound,on the efficacy and quality of life of patients with Dysphagia after stroke of kidney deficiency and phlegm stasis type.【Methods】A total of 64 patients with dysphagia after stroke were randomly divided into two groups,with 32 cases in each group.The control group received swallowing training,while the observation group received Dihuang Yinzi treatment on the basis of swallowing training.The efficacy of two groups of patients was compared,and the quality of life was evaluated using the WHOQOL-BREF scale as an evaluation tool.The differences in the total quality of life score and four domain scores between the two groups of patients were observed.【Results】The total effective rate of the observation group was 84.38%(27/32),which was higher than the control group's 62.5%(20/32).There was a statistically significant difference between the two groups(P<0.05),and no adverse events occurred in either group of patients.There was no statistically significant difference in the quality of life scores between the two groups of patients before treatment(all P>0.05);After treatment,the quality of life scores of both groups of patients were higher than that before treatment,and the difference was statistically significant(P<0.05).After treatment,the overall quality of life score and environmental and physiological scores of the observation group were higher than those of the control group(P<0.05);There was no statistically significant difference in the scores of social relations and psychology between the two groups(P>0.05).【Conclusions】Targeted drug penetration of Dihuang Yinzi combined with swallowing training can significantly improve the quality of life of patients with Dysphagia after stroke,with good safety.

关 键 词：卒中/中西医结合疗法 肾虚痰瘀 吞咽障碍 治疗结果 生活质量 

分 类 号：R743.3[医药卫生—神经病学与精神病学]