sPD-L1、IL-8、T细胞亚群水平变化与颅内肿瘤切除术后并发颅内感染的相关性  

Correlation between Changes in Levels of sPD-L1,IL-8,and T Cell Subsets and Postoperative Intracranial Tumor Resection

作　　者：魏长杰[1] 张进巧 WEI Chang-jie;ZHANG Jin-qiao(Xi'an Electric Power Central Hospital,Xi'an Shaanxi 710032)

机构地区：[1]西安电力中心医院,陕西西安710032

出　　处：《医学临床研究》2023年第6期888-891,共4页Journal of Clinical Research

摘　　要：【目的】探讨可溶性程序死亡配体1(sPD-L1)、白介素-8(IL-8)、T细胞亚群水平与颅内肿瘤切除术后并发颅内感染的相关性。【方法】选取2019年7月至2021年9月在本院行颅内肿瘤切除术的126例患者,根据术后7 d是否并发颅内感染分为感染组(n=84)和未感染组(n=42)。比较两组及不同感染类型患者sPD-L1、IL-8、T细胞亚群水平及神经功能损伤指标、氧化应激指标水平,采用Spearman相关系数分析sPD-L1、IL-8、T细胞亚群水平与颅内感染类型、神经功能损伤指标、氧化应激指标的相关性。【结果】与未感染组术后7 d比较,感染组确诊颅内感染时血清sPD-L1、IL-8、CD8^(+)水平较高,CD3^(+)、CD4^(+)水平较低,差异有统计学意义(P<0.05)。确诊颅内感染时血清sPD-L1、IL-8、CD8^(+)水平比较:细菌性颅内感染组>结核性颅内感染组>病毒性颅内感染组(P<0.05);CD3^(+)、CD4^(+)水平比较:细菌性颅内感染组<结核性颅内感染组<病毒性颅内感染组(P<0.05)。确诊感染时血清中枢神经特异性蛋白(S-100β)、神经元特异性烯醇化酶(NSE)、超氧歧化酶(SOD)水平比较:细菌性颅内感染>结核性颅内感染>病毒性颅内感染(P<0.05);丙二醛(MDA)水平比较:细菌性颅内感染<结核性颅内感染<病毒性颅内感染(P<0.05)。血清sPD-L1、IL-8、CD8^(+)水平与S-100β、NSE、SOD呈正相关(P<0.05),与MDA呈负相关(P<0.05);CD3^(+)、CD4^(+)水平与S-100β、NSE、SOD呈负相关(P<0.05),与MDA呈正相关(P<0.05)。【结论】颅内肿瘤切除术后血清sPD-L1、IL-8、T细胞亚群水平与颅内感染的发生密切相关,可为临床早期辅助诊断颅内感染类型及评估病情提供参考,有利于制定治疗方案。【Objective】To investigate the correlation between interleukin-8(IL-8),soluble programmed death ligand 1(sPD-L1),T cell subpopulation levels,and intracranial infection after intracranial tumor resection.【Methods】A total of 126 patients who underwent intracranial tumor resection in our hospital from July 2019 to September 2021 were selected and divided into an infected group(n=84)and an uninfected group(n=42)based on whether infection occurred 7 days after surgery.We compared the levels of sPD-L1,IL-8,T cell subpopulations,neurological impairment indicators,and oxidative stress indicators between two groups and patients with different infection types.We used Spearman correlation coefficient to analyze the correlation between sPD-L1,IL-8,T cell subpopulations,intracranial infection types,neurological impairment indicators,and oxidative stress indicators.【Results】Compared with the uninfected group 7 days after surgery,the infected group had higher levels of sPD-L1,IL-8,and CD8^(+)in serum at the time of confirmed infection,while lower levels of CD3^(+)and CD4^(+)were observed,with statistically significant differences(P<0.05).The comparison of serum sPD-L1,IL-8,and CD8^(+)levels during infection was confirmed:bacterial intracranial infection group>tuberculous intracranial infection group>viral intracranial infection group(P<0.05);Comparison of CD3^(+)and CD4^(+)levels:the Bacterial intracranial infection group<the tuberculous intracranial infection group<the viral intracranial infection group(P<0.05).Comparison of serum S-100β,NSE,and SOD levels during infection:bacterial intracranial infection>tuberculous intracranial infection>viral intracranial infection(P<0.05)was diagnosed;MDA levels were compared:bacterial intracranial infection<tuberculosis intracranial infection<viral intracranial infection(P<0.05).The serum levels of sPD-L1,IL-8,and CD8^(+)were positively correlated with S-100β,NSE,and SOD(P<0.05),and negatively correlated with MDA(P<0.05);The levels of CD3^(+)and CD4^(+)were negatively correla

关 键 词：脑肿瘤/外科学 手术后并发症 感染 B7-H1抗原 白细胞介素8 T淋巴细胞亚群 

分 类 号：R739.41[医药卫生—肿瘤]