帕利哌酮联合养血清脑颗粒对首发急性期精神分裂症患者血清BDNF水平、事件相关脑电位N400及认知功能的影响  

Effects of pariperidone combined with Yangxue Qingnao Granule on serum BDNF level, event-related potential N400 and cognitive function in patients with first-episode acute schizophrenia

作　　者：狄丽丽 刘海净[2] 李超[2] 付玉忠 王健[3] DI Li-li;LIU Hai-jing;LI Chao(Mental Health Center,Kailuan General Hospital,Tangshan Hebei 063000,China;Department of Pharmacy,Kailuan General Hospital,Tangshan Hebei 063000,China)

机构地区：[1]开滦总医院精神卫生中心,河北唐山063000 [2]开滦总医院药剂科,河北唐山063000 [3]开滦总医院风湿免疫科,河北唐山063000

出　　处：《临床和实验医学杂志》2023年第12期1266-1270,共5页Journal of Clinical and Experimental Medicine

基　　金：河北省卫健委科研基金项目(编号:20191322)。

摘　　要：目的分析帕利哌酮联合养血清脑颗粒对首发急性期精神分裂症患者血清脑源性神经营养因子(BDNF)、事件相关脑电位(ERP)N400(ERP-N400)及认知功能的影响。方法前瞻性选取2020年5月至2022年9月开滦总医院收治的136例首发急性期精神分裂症患者作为研究对象。按随机数字表法分为观察组与对照组,每组68例。对照组采用帕利哌酮治疗,口服,起始剂量为3.0 mg/d,1周内逐渐追加至6.0~12.0 mg/d;观察组采用帕利哌酮联合养血清脑颗粒治疗,口服,起始剂量为6.0 mg/d,最大剂量为12.0 g/d,疗程均3个月。统计两组血清BDNF水平、ERP-N400数据、精神分裂症认知功能成套测验(MCCB)中文版评分、社会功能个人与社会表现量表(PSP)评分、临床疗效及不良反应发生率,并进行统计学分析。结果治疗后,两组的血清BDNF水平、MCCB评分、PSP评分均较治疗前明显升高,且观察组治疗后的血清BDNF水平、MCCB评分、PSP评分分别为(44.13±9.38)ng/mL、(51.51±4.67)分、(74.21±5.88)分,均高于对照组[(33.22±9.28)ng/mL、(48.83±5.11)分、(65.94±4.80)分],差异均有统计意义(P<0.05)。治疗后,两组ERP-N400潜伏期均较治疗前显著缩短,ERP-N400波幅均较治疗前明显增大,差异均有统计学意义(P<0.05);两组ERP-N400潜伏期、ERP-N400波幅比较,差异均无统计意义(P>0.05)。观察组的临床总有效率为95.59%,显著高于对照组(83.82%),差异有统计意义(P<0.05)。观察组不良反应总发生率为11.76%,显著低于对照组(30.88%),差异有统计意义(P<0.05)。结论帕利哌酮联合养血清脑颗粒治疗首发急性期精神分裂症,有助于提高BDNF水平,改善患者认知功能,提高临床疗效,降低不良反应发生率,值得临床予以推广应用。Objective To analyze the effects of palipexone combined with Yangxue Qingnao Granule on serum brain-derived neurotrophic factor(BDNF),event-related potential(ERP)N400(ERP-N400)and cognitive function in patients with first-episode acute schizophrenia.Methods A total of 136 first-episode acute schizophrenia patients admitted to Kailuan General Hospital from May 2020 to September 2022 were selected as the study subjects.According to the method of random number table,they were divided into the control group and the observation group,68 patients in each group.The control group was treated with paliperidone orally,the initial dose was 3.0 mg/d,and gradually increased to 6.0~12.0 mg/d within one week;the observation group was treated with paliperidone combined with Yangxue Qingnao Granule,orally,with the initial dose of 6.0 mg/d and the maximum dose of 12.0 g/d,and the course of treatment was 3 months.The serum BDNF level,ERP-N400 data,scores of the Chinese version of the MATRICS consensus cognitive battery(MCCB)for schizophrenia,scores of the social function personal and social performance scale(PSP),clinical efficacy and the incidence of adverse reactions of the two groups were statistically analyzed.Results After treatment,the serum BDNF levels,MCCB scores,and PSP scores of the two groups were significantly higher than those before treatment,and the serum BDNF levels,MCCB scores,and PSP scores of the observation group after treatment were(44.13±9.38)ng/mL,(51.51±4.67)points,and(74.21±5.88)points,respectively,which were higher than those of the control group[(33.22±9.28)ng/mL,(48.83±5.11)points,and(65.94±4.80)points],the differences were statistically significant(P<0.05).After treatment,the incubation period of ERP-N400 was significantly shortened,and the amplitude of ERP-N400 was significantly increased,the differences were statistically significant(P<0.05).There was no statistically significant difference in ERP-N400 latency and ERP-N400 amplitude between the two groups(P>0.05).The total clinical effective rat

关 键 词：精神分裂症 帕利哌酮 养血清脑颗粒 脑源性神经营养因子 事件相关脑电位N400 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]