特纳综合征患者生育及妊娠管理的研究进展  

Research progresses in fertility and pregnancy management in patients with Turner syndrome

作　　者：赵越[1] 阮祥燕[1] 谷牧青[1] 程姣姣 王月姣 金婧[1] Zhao Yue;Ruan Xiangyan;Gu Muqing;Cheng Jiaojiao;Wang Yuejiao;Jin Jing(Department of Gynecological Endocrinology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University/Beijing Maternal and Child Health Care Hospital,Beijing 100026,China)

机构地区：[1]首都医科大学附属北京妇产医院/北京妇幼保健院内分泌科,北京100026

出　　处：《首都医科大学学报》2023年第4期561-567,共7页Journal of Capital Medical University

基　　金：北京市自然科学基金项目(7202047);北京市教育委员会科技发展计划一般项目(KM202010025009);首都卫生发展科研专项(2020-2-2112);北京市医院管理中心“登峰”人才培养计划项目(DFL20181401)。

摘　　要：妊娠是特纳综合征(Turner syndrome,TS)患者的关键问题,尽管4%~7%的TS患者有自然妊娠可能,但大多数女性需要借助卵母细胞捐献和生育力保护。由于卵巢功能减退通常发生在TS患者的生命早期,且妊娠可加重TS孕产妇基础心血管疾病进展或恶化的风险,如主动脉夹层或破裂等致死性并发症。因此,TS女性应该在孕前、妊娠期间和产后接受全面的心血管评估和多学科团队管理,以确保TS女性良好的生育结果。卵巢组织冻存技术是一种具有特定益处、适应证的个性化保护策略,有可能成为TS患者保护生育能力的重要工具。本文主要综述TS患者生育及妊娠管理的研究进展。Pregnancy is a key problem for patients with Turner syndrome(TS).Although 4%-7%of TS patients have the possibility of natural pregnancy,most TS patients need oocyte donation and fertility protection(FP).As premature ovarian failure generally occurs early in life of women with TS,and pregnancy can increase the risk of cardiovascular abnormalities,such as aortic dissection or rupture,these patients should be counseled and evaluated as early as possible for discussion of optimal cardiovascular assessment as well as multidisciplinary team management strategies.This supervision mode is also applicable to pre-pregnancy,pregnancy,and post-pregnancy.Ovarian tissue cryopreservation is a viable option for FP in young individuals with TS.This review summarizes the research progresses of fertility and pregnancy management for women with TS.

关 键 词：特纳综合征 生育力保护 卵巢组织冻存 妊娠风险 孕期监测 

分 类 号：R711[医药卫生—妇产科学]