MR扩散加权成像联合血清IP-10、GPC3检测在原发性肝癌诊断中的临床价值  

Clinical Value of MR Diffusion-weighted Imaging Combined with Serum IP-10 and GPC3 Detection in the Diagnosis of Primary Liver Cancer

作　　者：李恒 袁俊建[2] 许艳东 郭庆金 李国策[5] 柴伟[2] 张执全[2] 刘汝海[2] Li Heng;Yuan Jun-jian;Xu Yan-dong;Guo Qing-jin;Li Guo-ce;Chai Wei;Zhang Zhiquan;Liu Ru-hai(General Surgery Department of Cangzhou Heping Hospital,Cangzhou 061000,Hebei Province,China;The First Department of Hepatobiliary and Pancreatic Surgery,Cangzhou Central Hospital,Cangzhou 061000,Hebei Province,China;The Second People's Hospital of Renqiu City,Cangzhou 062550,Hebei Province,China;Colorectal Surgery Department of Cangzhou Central Hospital,Cangzhou 061000,Hebei Province,China;Nuclear magnetic resonance room of Cangzhou Central Hospital,Cangzhou 061000,Hebei Province,China)

机构地区：[1]沧州和平医院普外科,河北沧州061000 [2]沧州市中心医院肝胆胰外一科,河北沧州061000 [3]任丘市第二人民医院,河北沧州062550 [4]沧州市中心医院结直肠外科,河北沧州061000 [5]沧州市中心医院核磁室,河北沧州061000

出　　处：《中国CT和MRI杂志》2023年第7期119-121,共3页Chinese Journal of CT and MRI

基　　金：河北省医学科学研究课题计划项目(No.20211343)。

摘　　要：目的探讨MR扩散加权成像联合血清干扰素γ诱导蛋白10(IP-10)、磷脂酰肌醇蛋白聚糖-3(GPC3)检测在原发性肝癌诊断中的临床价值。方法选取本院2020年5月至2022年5月期间收治的102例疑似原发性肝癌患者,经病理诊断结果显示,有85例患者确诊为原发性肝癌,将其纳入实验组。另选取同期84例肝硬化患者为对照组。酶联免疫吸附(ELISA)法检测各组血清IP-10、GPC3水平。ROC曲线分析血清IP-10、GPC3水平对原发性肝癌的诊断价值。采用四格表分析MR扩散加权成像联合血清IP-10、GPC3检测对原发性肝癌的诊断效能。结果与对照组相比,实验组血清IP-10和GPC3表达水平均升高,差异均具有统计学意义(P<0.05)。经病理诊断结果显示,85例患者确诊为原发性肝癌。MR扩散加权成像诊断结果显示,有71例患者诊断为阳性,其灵敏度为80.00%(68/85),特异度为82.35%(14/17),准确度为80.39%(82/102)。MR扩散加权成像联合血清IP-10、GPC3诊断原发性肝癌的灵敏度、准确度均最高,三者联合的灵敏度82/85(96.47%)显著高于MR扩散加权成像80.00%(68/85)、GPC3单独诊断87.06%(74/85)(P<0.05),三者联合的准确度93.14(95/102)显著高于MR扩散加权成像80.39%(82/102)(P<0.05)。结论原发性肝癌患者血清中IP-10、GPC3表达水平升高,IP-10、GPC3对原发性肝癌有一定诊断价值,联合MR扩散加权成像可明显提高原发性肝癌诊断的灵敏度和准确度。Objective To investigate the clinical value of MR diffusion-weighted imaging combined with detection of serum interferonγ-inducible protein 10(IP-10)and glypican-3(GPC3)in the diagnosis of primary liver cancer.Methods A total of 102 patients with suspected primary liver cancer who were admitted to our hospital from May 2020 to May 2022 were selected.The pathological diagnosis showed that 85 patients were diagnosed with primary liver cancer and included in the experimental group.Another 84 patients with liver cirrhosis were selected as the control group.Serum IP-10 and GPC3 levels in each group were detected by enzyme-linked immunosorbent assay(ELISA).ROC curve was used to analyze the diagnostic value of serum IP-10 and GPC3 levels in the diagnosis of primary liver cancer.The four-table table was used to analyze the diagnostic efficacy of MR diffusion-weighted imaging combined with serum IP-10 and GPC3 detection for primary liver cancer.Results Compared with the control group,the expression levels of serum IP-10 and GPC3 in the experimental group were increased(P<0.05).The pathological diagnosis showed that 85 patients were diagnosed with primary liver cancer.The diagnostic results of MR diffusion-weighted imaging showed that 71 patients were diagnosed as positive,with a sensitivity of 80.00%(68/85),a specificity of 82.35%(14/17),and an accuracy of 80.39%(82/102).MR diffusion-weighted imaging combined with serum IP-10 and GPC3 had the highest sensitivity and accuracy in diagnosing primary liver cancer,the sensitivity of the three combination was 82/85(96.47%),which was greatly higher than 80.00%(68/85)of MR diffusion-weighted imaging,and 87.06%(74/85)of GPC3(P<0.05),the combined accuracy of the three combination,93.14(95/102),was greatly higher than 80.39%(82/102)of MR diffusion-weighted imaging(P<0.05).Conclusion The expression levels of IP-10 and GPC3 in serum of patients with primary liver cancer are increased.IP-10 and GPC3 have certain diagnostic value for primary liver cancer.Combining MR diffusion-weighted

关 键 词：原发性肝癌 MR扩散加权成像 干扰素γ诱导蛋白10 磷脂酰肌醇蛋白聚糖-3 诊断价值 

分 类 号：R575[医药卫生—消化系统]