结晶母液回收D-对羟基苯甘氨酸的工艺优化研究  

Study on Process Optimization of Recovery of D-p-hydroxyphenylglycine from Crystallization Mother Liquor

作　　者：许萍 刁玉段 胡晓霞 张香治 刘小杰 XU Ping;DIAO Yu-duan;HU Xiao-xia;ZHANG Xiang-zhi;LIU Xiao-jie(Shanghai Urban Construction Vocational College,Shanghai 201415,China;Institute of Animal Husbandry&Veterinary Science,Shanghai Academy of Agricultural Sciences,Shanghai 201101,China;Novasep Asia Co.,Ltd.,Shanghai 201203,China)

机构地区：[1]上海城建职业学院,上海201415 [2]上海市农业科学院畜牧兽医研究所,上海201101 [3]诺华赛分离技术(上海)有限公司,上海201203

出　　处：《粮油食品科技》2023年第4期138-144,共7页Science and Technology of Cereals,Oils and Foods

基　　金：上海城建职业学院2022年度校级科研项目(cjky202224)。

摘　　要：D-对羟基苯甘氨酸(D-HPG)是合成甜味剂、药物的重要中间体,为降低工艺成本,提高产品质量,提出了一种结晶母液回收D-HPG的连续色谱新工艺。优选纳滤膜进行前处理,增浓结晶母液,筛选Applexion NF200纳滤膜增浓D-HPG效果较好。通过单柱实验筛选连续色谱系统填料树脂,其中Applexion XA945树脂对D-HPG和硫酸铵分离度可达16。进一步对色谱系统的分离效果进行研究,结果表明,经连续色谱分离后,进料液中D-HPG平均纯度由42.2%提高至96.3%,平均收率达91%。利用连续色谱系统从结晶母液中回收D-HPG,是较有前途的工艺。与传统工艺相比,新工艺既保证了D-HPG总收率,又降低其工艺成本,提高了产品质量。D-p-hydroxyphenylglycine(D-HPG)is an important intermediate for the synthesis of sweeteners and drugs.An innovative continuous chromatographic process was developed to recover D-HPG from crystallization mother liquor,with the aim of reducing the process cost and improving the quality of D-HPG.The thickening properties of different nanofiltration membranes on mother liquor were investigated by pre-treatment test,and the Applexion NF200 nanofiltration membrane was selected to enrich D-HPG.The separation properties of different resins were analyzed by single column experiment,and the separation degree of Applexion XA945 resin to D-HPG and ammonium sulfate could reach 16.Based on the results,the way of sequential simulated moving bed separation was further studied.The results showed that after separation by the sequential simulated moving bed,the average purity of D-HPG in feeding was increased from 42.2%to 96.3%,and the average yield was 91%.The continuous chromatographic system is a promising method for the recovery of D-HPG from crystallization mother liquor.Compared with the traditional process,the new process not only ensures the total yield of D-HPG,but also greatly reduces the process cost and improves the product quality.

关 键 词：D-对羟基苯甘氨酸 结晶母液 顺序模拟移动床 回收工艺优化 

分 类 号：TS201.1[轻工技术与工程—食品科学] Q815[轻工技术与工程—食品科学与工程]