NIR‑II‑Triggered Composite Nanofibers to Simultaneously Achieve Intracranial Hemostasis,Killing Superbug and Residual Cancer Cells in Brain Tumor Resection Surgery  

作　　者：Jun Yang Lei Xu Yining Ding Chang Liu Bingchang Wang Yanchao Yu Chao Hui Seeram Ramakrishna Jun Zhang Yunze Long 

机构地区：[1]Collaborative Innovation Center for Nanomaterials&Devices,College of Physics,Qingdao University,Qingdao 266071,People’s Republic of China [2]Center for Nanofibers&Nanotechnology,Department of Mechanical Engineering,National University of Singapore,Singapore 117574,Singapore

出　　处：《Advanced Fiber Materials》2023年第1期209-222,共14页先进纤维材料（英文）

基　　金：supported by a grant from the National Natural Science Foundation of China(11904193 and 51973100);State Key Laboratory of Bio-Fibers and Eco-Textiles,Qingdao University(RZ2000003334 and G2RC202022);the National Key Research and Development Program(2019YFC0121402).

摘　　要：Malignant glioblastoma(GBM)is prone to relapse due to the inevitable tumor cells residue by surgery.During the tumor resection surgery in brain,addressing bleeding and superbug infections is also full of challenges.Currently,no method or material in clinical craniotomy can simultaneously solve these three problems.Herein,Chitosan composite nanofibers embed-ded with CuSe nanoparticles were prepared by green electrospinning method,in which the CuSe nanoparticles have strong absorption in the second near-infrared(NIR-II)window.Immediately after removing the tumor in craniotomy,nanofibers were electrospun and deposited directly onto the resection site with high precision(>90%)to achieve rapid hemostasis(<8 s).Moreover,evidenced by the deeper penetration depth of NIR-II light(1064 nm)both in the scalp and skull than NIR-I light(808 nm),photothermal and photodynamic therapy induced by NIR-II exhibits efficient superbug-killing rate(>99%)and effectively induces cell apoptosis of residual tumor thereby to inhibit tumor recurrence.Only using the same material,a tril-ogy of intracranial hemostasis,killing superbug and residual cancer cells is simultaneously achieved.The short operation time reduces the risk of craniotomy.This electrospinning strategy could combine with craniotomy and minimally invasive surgery,which may provide novel perspectives in clinical operation besides craniotomy.

关 键 词：Electrospinning Anti-tumor ANTI-MICROBIAL HEMOSTASIS 

分 类 号：R73[医药卫生—肿瘤] R318[医药卫生—临床医学] TB383[一般工业技术—材料科学与工程]