Microwave triggered multifunctional nanoplatform for targeted photothermal-chemotherapy in castration-resistant prostate cancer  

作　　者：Pengyuan Liu Yajun Wu Xiaogang Xu Xudong Fan Chuan Sun Xiaojie Chen Jindan Xia Shiting Bai Li Qu Huasong Lu Jing Wu Jun Chen Ji-Gang Piao Zhibing Wu 

机构地区：[1]Department of Oncology,Affiliated Zhejiang Hospital,Zhejiang University School of Medicine,Hangzhou 310013,China [2]School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China [3]Department of Radiation Oncology,Affiliated Zhejiang Hospital,Zhejiang University School of Medicine,Hangzhou 310013,China [4]Geriatrics Institute of Zhejiang Province,Department of Geriatrics,Affiliated Zhejiang Hospital,Zhejiang University School of Medicine,Hangzhou 310030,China [5]Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology,Life Sciences Institute,Zhejiang University,Hangzhou 310058,China [6]TCM Dispensary,Affiliated Zhejiang Hospital,Zhejiang University School of Medicine,Hangzhou 310013,China [7]Department of Breast Surgery,Affiliated Hangzhou First People’s Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China

出　　处：《Nano Research》2023年第7期9688-9700,共13页纳米研究（英文版）

基　　金：This study was supported by the National Natural Science Foundation of China(Nos.82172679 and 82104405);Zhejiang Provincial Medicine and Health Science Foundation(No:2021KY010).

摘　　要：Lacking a precise targeting strategy,castration-resistant prostate cancer(CRPC)is still hard to be treat effectively.Exploring treatment options that can accurately target CPRC is an important issue with urgent need.In this study,a novel nanotechnologybased strategy had been developed for the precise target treatment of CRPC.By combining microwaves and photothermal therapy(PTT),this nanoplatform,cmHSP70-PL-AuNC-DOX,targets tumor tissues with outstanding precision and achieves better anti-tumor activity by simultaneously eliciting photothermal and chemotherapeutic effects.From nanotechnology,cmHSP70-modified and thermo-sensitive liposome-coated AuNC-DOX were prepared and used for CRPC-targeted photothermal ablation and chemotherapy.Doxorubicin(DOX)was selected as the chemotherapeutic agent for cytotoxicity.In terms of the curative scheme,prostate tissues were firstly pre-treated with microwaves to induce the expression of heat shock protein 70(HSP70)and its migration to the cell membrane,which was then targeted by HSP70 antibody(cmHSP70)coated on the nanoparticles to achieve accurate drug delivery.The nanoplatform then achieved precise ablation and controlled release of DOX under external near-infrared(NIR)irradiation.Through the implementation,the targeting,cell killing,and safety of this therapeutical strategy had been verified in vivo and in vitro.This work establishes an accurate,controllable,efficient,non-invasive,and safe treatment platform for targeting CRPC,provides a rational design for CRPC’s PTT,and offers new prospects for nanomedicines with great precision.

关 键 词：castration-resistant prostate cancer gold nanocage heat shock protein 70 targeted drug delivery photothermalchemotherapy 

分 类 号：R737.25[医药卫生—肿瘤]