Evoking robust immunogenic cell death by synergistic sonodynamic therapy and glucose depletion using Au clusters/single atoms modified TiO_(2)nanosheets  

作　　者：Xiuxin Lu Kun Qiao Firdoz Shaik Yang Zheng Zhaoyou Chu Haisheng Qian Xijun Liu Weiqing Zhang 

机构地区：[1]Department of Research,Guangxi Medical University Cancer Hospital,Nanning 530021,China [2]Department of Breast Surgery,Harbin Medical University Cancer Hospital,Harbin 150081,China [3]Department of Biotechnology,Vignan’s Foundation for Science,Technology&Research,Guntur 522213,India [4]Department of Breast Surgery,Guangxi Medical University Cancer Hospital,Nanning 530021,China [5]School of Biomedical Engineering,Research and Engineering Center of Biomedical Materials,Anhui Provincial Institute of Translational Medicine,Anhui Medical University,Hefei 230032,China [6]State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures,School of Resource,Environments and Materials,Guangxi University,Nanning 530004,China

出　　处：《Nano Research》2023年第7期9730-9742,共13页纳米研究（英文版）

基　　金：The authors gratefully acknowledge the financial supports provided by the National Natural Science Foundation of China(No.21902119);Guangxi Provincial Natural Science Foundation(No.GUIKEAD22035044);Advanced Innovation Teams and Xinghu Scholars Program of Guangxi Medical University,and start-up funding for high-level talents from Guangxi Medical University Cancer Hospital。

摘　　要：Facilitated by reactive oxygen species(ROS)-involved therapies,tumor cells undergo immunogenic cell death(ICD)to stimulate long-term immunity response.However,it is hard to trigger abundant and large-scale ICD for satisfactory cancer immunotherapy.Herein,a multifunctional sonosensitizer that consists of Au single atoms and clusters anchored on TiO_(2)nanosheets(named Au_(S/C)-TiO_(2))is reported for augmented sonodynamic therapy(SDT)and glucose depletion,which ultimately induce robust ICD due to the improved ROS generation and strong endoplasmic reticulum(ER)stress.The synergy effect between Au cluster/single atom with TiO_(2)nanosheets intensifies apoptosis and ICD pathways to inhibit 80%of tumor cells through in vivo analyses.Furthermore,immune cells in vivo analyses verify the effectiveness of Au_(S/C)-TiO_(2)sonosensitizer towards the induction of antitumor immunity.This study thus reveals that simultaneous presence of ROS generation and strong ER stress can efficiently evoke a strong ICD-mediated immune response.

关 键 词：single atom cluster TITANIA sonodynamic therapy immunogenic cell death MULTIFUNCTIONAL 

分 类 号：R730.51[医药卫生—肿瘤]