Papillary fibroblast-recruiting injectable self-healing multifunctional hydrogels for wound regeneration  

作　　者：Yueyue Li Weifeng Zhong Junjie Wu Yuan Jia Zhonghua Chen Kaiwen Zhang Danyang Guo Yifei Fu Mengnan Chen Weiwei Chen Fan Tian Xia Li Hongji Zhang Xiaojin Zhou Feng-Lai Yuan 

机构地区：[1]Institute of Integrated Chinese and Western Medicine,Affiliated Hospital of Jiangnan University,Wuxi 214000,China [2]The Key Laboratory of Synthetic and Biological Colloids,Ministry of Education,School of Chemical and Material Engineering,Jiangnan University,Wuxi 214000,China

出　　处：《Nano Research》2023年第7期9792-9803,共12页纳米研究（英文版）

基　　金：Funding for this study was provided by the Natural Science Foundation of Jiangsu Province(No.BK20191141);Top Talent Support Program for Young and Middle-aged People of Wuxi Health Committee(Nos.BJ2020044,BJ2020057,and HB2020043);Fundamental Research Funds of Health and Family Planning Commission of Wuxi(No.M202024);the Special Program for Translational Medicine Research of Wuxi Translational Medicine Center(Nos.2020DHYB07 and 2020DHYB03);Key Special Project of Precision Medicine of Wuxi Health Commission(No.J202101).

摘　　要：The recruitment of key cells to regeneration sites is a promising strategy to promote functional wound healing.Dermal fibroblasts exhibit a heterogeneous population of cells during homeostasis and in response to injury.Papillary fibroblasts play central regulatory roles in the regeneration of skin appendages during wound healing.Inspired by the phenomenon where bait for grass carp can attract grouped grass carps to a fishing spot soon,“Grass Carp Fishing”multifunctional hydrogels,that is,codelivery of an antibody of leucine-rich repeats and immunoglobulin-like domains 1(Lrig1)on the surface of papillary fibroblasts and insulinlike growth factor 1(IGF1)with recruitment function,can recruit papillary fibroblasts.In the experiments,carboxymethyl chitosan showed positive effects in promoting cell proliferation and neovascularization,while dopamine-grafted gelatin was effective in stabilizing the structure and prolonging the degradation time.The sustained release of Lrig1 antibodies and IGF1 from injectable self-healing multifunctional hydrogels persistently accelerated the migration and proliferation of Lrig1+fibroblasts.The in vivo results from a full-thickness cutaneous wound model showed that injectable self-healing multifunctional hydrogel accelerated wound healing and skin regeneration through the recruitment of Lrig1+papillary fibroblasts in wound tissue.Our findings reveal an injectable self-healing multifunctional hydrogel for regeneration,a promising approach to promoting skin wound healing.

关 键 词：wound healing REGENERATION papillary fibroblasts recruitment 

分 类 号：O63[理学—高分子化学]