Tumor microenvironment-responsive modular integrated nanocomposites for magnetically targeted and photothermal enhanced catalytic therapy  

作　　者：Yuan Liang Yilin Liu Pengpeng Lei Zhen Zhang Hongjie Zhang 

机构地区：[1]State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,5625 Renmin Street,Changchun 130022,China [2]School of Materials Science and Engineering,Sun Yat-sen University,Guangzhou 510275,China [3]School of Rare Earths,University of Science and Technology of China,Hefei 230026,China [4]Ganjiang Innovation Academy,Chinese Academy of Sciences,Ganzhou 341000,China [5]Department of Chemistry,Tsinghua University,Beijing 100084,China

出　　处：《Nano Research》2023年第7期9826-9834,共9页纳米研究（英文版）

基　　金：This work was supported by the financial aid from the National Natural Science Foundation of China(Nos.22020102003,21834007,and 52103276);the National Key R&D Program of China(No.2020YFA0712102);the Program of Science and Technology Development Plan of Jilin Province of China(No.20220508076RC);the Natural Science Foundation of Guangdong Province of China(No.2022A1515010947);Guangzhou Basic and Applied Basic Research Foundation(No.202201011343).

摘　　要：Achieving efficient integration of cancer diagnosis and therapy is of great significance to human health,but the construction of a multifunctional intelligent therapy system still faces great challenges.In this study,we report an integrated multifunctional nanocomposite constructed by a simple modular assembly technology.The nanocomposites are composed of three different nanomaterials:Fe_(3)O_(4),Au,and NaErF_(4):0.5%Tm@NaYF_(4)upconversion nanoparticles(UCNPs).In this design,Fe_(3)O_(4)nanoparticles have nanozyme effect of peroxidase-like activity,which can react with H_(2)O_(2)in the tumor microenvironment to generate hydroxyl radicals.Because of its magnetic properties,it can help the nanocomposites to aggregate under the induction of magnetic fields.Au nanoparticles exhibit nanozyme effect of glucose oxidase-like activity.It can catalyze the conversion of glucose to gluconic acid and H_(2)O_(2).Ingeniously,the generated H_(2)O_(2)provides a source of reactants for the reaction of the Fe_(3)O_(4)nanozyme.In addition,the photothermal effect of Au nanoparticles under 808 nm irradiation further enhanced the nanozyme activity of Fe_(3)O_(4)and Au nanoparticles.Besides,UCNPs can emit near-infrared(NIR)-II fluorescence under 808 nm irradiation,which can provide imaging-guided during cancer treatment.Then,the nanocomposites were further modified by poly(vinylpyrrolidone)(PVP)to obtain UCNPs/Au/Fe_(3)O_(4)-PVP with good biocompatibility and high-efficiency cancer treatment ability.

关 键 词：modular integrated magnetic induction photothermal effect near-infrared(NIR)-II imaging nanozyme catalyzed reactions 

分 类 号：TB33[一般工业技术—材料科学与工程] R730.5[医药卫生—肿瘤]