TRAIP在原发性肝细胞癌中表达及其在病理诊断和预后中的意义  

Expression of TRAIP in hepatocellular carcinoma and its significance in pathological diagnosis and prognosis

作　　者：蔡小艳 马登云[1] 逯金海[1] 马颖才[2] CAI Xiao-yan;MA Deng-yun;LU Jin-hai(Department of Pathology,Qinghai Red Cross Hospital,Xining Qinghai,810001,China)

机构地区：[1]青海红十字医院病理科,青海西宁810001 [2]青海省人民医院消化内科

出　　处：《中西医结合肝病杂志》2023年第7期621-624,628,共5页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：青海省2019年创新平台建设专项项目(No.2019-SF-L5)。

摘　　要：目的:探讨肿瘤坏死因子受体相关因子相互作用蛋白(TRAIP)在原发性肝细胞癌(HCC)中表达及其在病理诊断和预后中的意义。方法:选取2017年2月至2019年2月医院收治的行手术切除并经病理学确诊的60例HCC患者为研究组,另选取同期在本院体检健康者60例设为对照组,比较两组血清TRAIP表达水平,分析TRAIP表达与HCC患者临床病理参数的关系,Kaplan-Meier法比较不同TRAIP表达水平HCC患者生存率,Cox比例风险回归模型分析HCC患者预后不良影响因素。结果:研究组患者TRAIP表达水平高于对照组(P<0.05);TRAIP表达水平与微血管侵犯、肿瘤淋巴结转移(TNM)分期和分化程度相关(P<0.05);Kaplan-Meier生存分析显示,TRAIP水平高表达组生存时间低于TRAIP水平低表达组(P<0.05);单因素Cox比例回归模型分析显示,肿瘤大小、微血管侵犯、TNM分期、分化程度及TRAIP表达与HCC患者预后相关(P<0.05);多因素Cox比例回归模型分析显示,肿瘤大小>4 cm、微血管有侵犯、TNM分期为Ⅲ~Ⅳ期、分化程度高、TRAIP呈高表达是HCC患者预后的独立危险因素(P<0.05)。结论:TRAIP在HCC中呈高表达,且与患者微血管侵犯、TNM分期和分化程度密切相关,其表达水平可作为HCC临床病理诊断指标,TRAIP高表达是HCC患者预后不良的独立危险因素,可成为预测HCC患者预后新靶点。Objective:To investigate the expression of tumor necrosis factor receptor-associated factor-interacting protein(TRAIP)in hepatocellular carcinoma(HCC)and its significance in pathological diagnosis and prognosis.Methods:A total of 60 patients who were admitted to the hospital for surgical resection and confirmed as HCC by pathology from February 2017 to February 2019 was selected as the research group,and 60 healthy patients who received physical examination in our hospital during the same period were selected as the control group.The expression levels of serum TRAIP between the two groups were compared,and the relationship between TRAIP expression and clinicopathological parameters of HCC patients was analyzed.Kaplan-Meier method was used to compare the survival rate of HCC patients with different TRAIP expression levels,and Cox proportional hazards regression model was used to analyze the prognostic factors of HCC patients.Results:The expression level of TRAIP in the study group was higher than that in the control group(P<0.05).The expression level of TRAIP was correlated with microvascular invasion,tumor node metastasis(TNM)stage,and differentiation degree(P<0.05).Kaplan-Meier survival analysis showed that the survival time of the high TRAIP expression group was lower than that of the low TRAIP expression group(P<0.05).Univariate Cox proportional regression model analysis showed that tumor size,microvascular invasion,TNM stage,degree of differentiation,and TRAIP expression were associated with the prognosis of HCC patients(P<0.05).Multivariate Cox proportional regression model analysis showed that tumor size>4 cm,microvascular invasion,TNM stageⅢ-Ⅳ,high differentiation degree,and high expression of TRAIP were independent risk factors for the prognosis of HCC patients(P<0.05).Conclusion:TRAIP is highly expressed in HCC,and is closely related to the microvascular invasion,TNM stage,and differentiation degree of patients.Its expression level can be used as a clinicopathological indicator for HCC diagnosis.High

关 键 词：原发性肝细胞癌 肿瘤坏死因子受体相关因子相互作用蛋白 泛素连接酶 病理诊断 预后 

分 类 号：R735.7[医药卫生—肿瘤]