Harnessing strategies for enhancing diabetic wound healing from the perspective of spatial inflammation patterns  

作　　者：Yixin Cai Kangli Chen Changsheng Liu Xue Qu 

机构地区：[1]Key Laboratory for Ultrafine Materials of Ministry of Education,School of Material Science and Engineering,Frontiers Science Center for Materiobiology and Dynamic Chemistry,East China University of Science and Technology,Shanghai,200237,China [2]Wenzhou Institute of Shanghai University,Wenzhou,325000,China [3]Shanghai Frontier Science Center of Optogenetic Techniques for Cell Metabolism,Shanghai,200237,China

出　　处：《Bioactive Materials》2023年第10期243-254,共12页生物活性材料（英文）

基　　金：Support from the National Natural Science Foundation of China(31922041,11932012,32171341);National key research and development program(2021YFB3800800);the 111 project(B14018);the Science and Technology Innovation Project and Excellent Academic Leader Project of Shanghai Science and Technology Committee(21S31901500,21XD1421100)are acknowledged.

摘　　要：Diabetic wound is a great threat to patient’s health and lives.The refractory diabetic wound shows spatial inflammation patterns,in which the early-wound pattern depicts a deprived acute inflammatory response,and the long-term non-healing wound pattern delineates an excessive and persistent inflammation due to the delayed immune cell infiltration in a positive feedback loop.In this work,we give points to some strategies to normalize the dysregulated immune process based on the spatial inflammation pattern differences in diabetic wound healing.First of all,inhibiting inflammatory response to avoid subsequent persistent and excessive immune infiltration for the early diabetic wound is proposed.However,diabetic wounds are unperceptive trauma that makes patients miss the best treatment time.Therefore,we also introduce two strategies for the long-term non-healing diabetic wound.One strategy is about changing chronic wounds to acute ones,which aims to rejuvenate M1 macrophages in diabetic wounds and make spontaneous M2 polarization possible.To activate the controllable proinflammatory response,western medicine delivers proinflammatory molecules while traditional Chinese medicine develops“wound-pus promoting granulation tissue growth theory”.Another strategy to solve long-term non-healing wounds is seeking switches that target M1/M2 transition directly.These investigations draw a map that delineates strategies for enhancing diabetic wound healing from the perspective of spatial inflammation patterns systematically.

关 键 词：Diabetic wound Spatial inflammation pattern M1/M2 transition BIOMATERIALS 

分 类 号：R587.1[医药卫生—内分泌]