家族史阳性首发未用药抑郁症患者的神经认知功能危险标记物  

Risk Markers for Neurocognitive Function in Patients with First-episode Untreated Depression and A Positive Family History

作　　者：程夏龙 张许来 关建军[1,2,3,4] 方文梅 张博宇[1,2,3,4] 王安珍 CHENG Xialong;ZHANG Xulai;GUAN Jianjun;FANG Wenmei;ZHANG Boyu;WANG Anzhen(Affiliated Psychological Hospital of Anhui Medical University,Hefei 230022,China;Anhui Mental Health Center,Hefei 230022,China;Hefei Fourth People’s Hospital,Hefei 230022,China;Anhui Clinical Research Center for Mental Disorders,Hefei 230022,China)

机构地区：[1]安徽医科大学附属心理医院,合肥230022 [2]安徽省精神卫生中心,合肥230022 [3]合肥市第四人民医院,合肥230022 [4]安徽省精神心理疾病临床研究中心,合肥230022

出　　处：《神经损伤与功能重建》2023年第7期404-408,共5页Neural Injury and Functional Reconstruction

基　　金：2018年合肥市科技局“借转补”项目(J2018Y05);2019年安徽省重点研究与开发计划项目(201904a07020009)。

摘　　要：目的:探究家族史阳性、家族史阴性首发未用药的抑郁症患者及健康人群之间神经认知功能差异,从而明确家族史阳性首发未用药的抑郁症患者特异性神经认知功能危险标记物。方法:入组32例家族史阳性首发未用药的抑郁症患者,36例家族史阴性首发未用药的抑郁症患者和35例健康志愿者,在经精神科药物干预前应用成套神经心理状态评估工具在即刻记忆、视觉广度、言语功能、注意力、延时记忆五个维度进行神经认知功能测评,应用汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)和汉密尔顿抑郁量表(Hamilton depression scale,HAMD)进行临床症状测评。结果:家族史阳性与阴性首发未用药的抑郁症患者的即刻记忆、视觉广度、言语功能、注意力、延时记忆五个神经认知功能维度的得分均明显低于健康人群(P<0.01)。家族史阳性首发未用药的抑郁症患者的即刻记忆、言语功能、注意力得分低于家族史阴性首发未用药的抑郁症患者(P<0.05)。Spearman相关分析显示家族史阳性首发未用药的抑郁症患者各个神经认知功能维度得分与HAMA评分、HAMD评分均无相关性。家族史阴性首发抑郁症患者延时记忆得分与HAMA评分呈负相关(P<0.05,r=-0.397),言语功能得分与HAMD评分呈负相关(P<0.05,r=-0.039)。结论:家族史阳性首发未用药的抑郁症患者神经认知功能方面可能预先存在的特异性标记,成套神经心理状态评估工具中的即刻记忆、言语功能、注意力维度可以考虑作为其神经认知危险标记物,其神经认知功能受损与临床症状可能并无相关性。Objective:To explore the differences in neurocognitive function among patients with first-episode untreated depression who had a positive family history,those with a negative family history,and the healthy population,so as to identify the specific risk markers of neurocognitive function in the patients with first-episode untreated depression and a positive family history.Methods:A total of 32 patients with first-episode untreated depression and a positive family history,36 patients with first-episode untreated depression and a negative family history,and 35 healthy volunteers were enrolled.The neuropsychological state assessment kit was used to measure neurocognitive function across five domains of immediate memory,visual span,speech function,attention,and delayed memory before psychiatric drug intervention,and the Hamilton Anxiety Rating Scale(HAMA)and Hamilton Depression Rating Scale(HAMD)were used to assess clinical symptoms.Results:The scores of immediate memory,visual span,speech function,attention,and delayed memory in the patients with first-episode untreated depression and a positive or negative family history were significantly lower than those in the healthy volunteers(P<0.01).The scores of immediate memory,speech function,and attention in patients with first-episode untreated depression and a positive family history were lower than those in patients with first-episode untreated depression and a negative family history(P<0.05).The results of Spearman’s correlation analysis showed that there were no correlations between the score of each domain of neurocognitive function and HAMA and HAMD scores in patients with first-episode untreated depression and a positive family history.In patients with first-episode untreated depression and a negative family history,the score of delayed memory was negatively correlated with HAMA score(P<0.05,r=-0.397),and the score of speech function was negatively correlated with HAMD score(P<0.05,r=-0.039).Conclusion:There may be preexisting specific markers of neurocognitive

关 键 词：首发未用药的抑郁症患者 家族史阳性 神经认知功能 危险标记物 

分 类 号：R741[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]