激光热疗皮下球形肿瘤的瞬态温度场模拟  

Simulation of Transient Temperature Field in Subcutaneous Spherical Tumor During Laser-Induced Thermotherapy

作　　者：蔡林璇 刘迪[1] 杨柳樾 王浩宇 毕娟[1] CAI Linxuan;LIU Di;YANG Liuyue;WANG Haoyu;BI Juan(School of Physics,Changchun University of Science and Technology,Changchun 130022)

机构地区：[1]长春理工大学物理学院,长春130022

出　　处：《长春理工大学学报（自然科学版）》2023年第3期23-28,共6页Journal of Changchun University of Science and Technology(Natural Science Edition)

基　　金：国家级大学生创新创业训练计划项目(202210186007);吉林省自然科学基金(20220101034JC,20210101186JC)。

摘　　要：激光热疗作为新兴高效的医疗手段,受到国内外学者的广泛关注,通过激光热疗的方法治疗肿瘤可以减少对健康组织的影响。为了获得热疗过程中的组织实时温度场变化情况,有必要开展热疗过程中的瞬态温度场研究。以皮下球形肿瘤为例,基于Pennes生物传热理论建立了激光热疗物理模型,并在模型中考虑到纳米颗粒注入肿瘤来提高激光吸收效率的情况,利用有限元方法模拟了热疗过程中的温度场时空分布。模拟结果表明,随着时间推移,组织温度逐渐升高,热疗过程中,肿瘤区的温升明显高于周围健康组织,最大温升位于肿瘤中心偏上,皮肤表面温度呈现高斯分布的特点。研究结果可以为肿瘤的临床治疗提供一定的理论参考。Laser-induced thermotherapy,as a new and efficient medical means,has received extensive attention from scholars at home and abroad.Treatment of tumors by laser-induced thermotherapy can reduce the impact on healthy tissues.In order to obtain the real-time temperature field changes of tissues during hyperthermia,it is necessary to conduct the transient temperature field studies.In this paper,taking the subcutaneous spherical tumor as an example,a physical model of laser-induced thermotherapy is established based on the Pennes's bioheat theory.In the model,the situation that nanoparticles are injected into the tumor to improve the laser absorption efficiency is considered,and the time-space distributions of the temperature fields during the hyperthermia process are simulated using the finite element method.The simulation results showed that the tissue temperature gradually increased with the passage of time;during hyperthermia,the temperature rise in the tumor area was significantly higher than that in the surrounding healthy tissues,and the maximum temperature rise was above the tumor center;the skin surface temperature was characterized by Gaussian distribution.The results of this study can provide a theoretical reference for the clinical treatment of tumors.

关 键 词：激光热疗 皮下肿瘤 瞬态温度场 有限元模拟 

分 类 号：R739.5[医药卫生—肿瘤] R318.51[医药卫生—临床医学]