胃苓散加味辅助人工肝治疗急性重型肝炎肝肾综合征的疗效观察  

Observation on the Effects of Modified Weiling Powder Assisting Artificial Liver for Patients with Acute Severe Hepatitis with Hepatorenal Syndrome

作　　者：李慧[1] 辜建勋[1] 吴登[1] Li Hui;Gu Jianxun;Wu Deng(Hubei Hospital of Traditional Chinese Medicine,Hubei,Wuhan 430061,China)

机构地区：[1]湖北省中医院,湖北武汉430061

出　　处：《中国中医急症》2023年第7期1216-1219,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号)。

摘　　要：目的 观察胃苓散加味辅助人工肝治疗急性重型肝炎肝肾综合征(肝气郁结、水湿中阻证)患者的临床疗效。方法 将106例急性重型肝炎肝肾综合征患者按随机数字表法分观察组与对照组各53例。对照组予人工肝治疗,观察组在人工肝等治疗的基础上辅助胃苓散加味治疗。比较两组临床总有效率、谷丙转氨酶(ALT)、血清总胆红素(TBIL)、血清白蛋白(ALB)、血尿素氮(BUN)、血肌酐(Scr)、胱抑素C(CysC)、24 h尿量,Na~+、K~+水平。结果 两组总有效率差异无统计学意义(P> 0.05)。两组治疗后ALT、TBIL水平显著低于治疗前,ALB水平显著高于治疗前,观察组治疗后ALT、TBIL水平显著低于对照组,ALB水平显著高于对照组(P <0.05)。两组治疗后BUN、Scr、CysC水平显著低于治疗前,24 h尿量显著高于治疗前(P <0.05);观察组BUN、Scr、CysC水平显著低于对照组,24 h尿量显著高于对照组(P <0.05)。两组治疗后Na~+、K~+水平显著高于治疗前,观察组治疗后Na~+、K~+水平显著高于对照组(P <0.05)。结论 胃苓散加味辅助人工肝治疗急性重型肝炎肝肾综合征(肝气郁结、水湿中阻证)可显著改善患者肝肾功能,提高电解质Na~+、K~+水平。Objective:To observe the effects of Modified Weiling Powder assisting artificial liver in patients with acute severe hepatitis with hepatorenal syndrome(liver-qi stagnation,fluid-damp blocking middle jiao).Methods:A total of 106 patients with acute severe hepatitis with hepatorenal syndrome were selected and divid-ed into an observation group and a control group according to random number table method,53 cases in each group.The control group was treated with artificial liver and other treatments,while the observation group was treated with Modified Weiling Powder on the basis of plasma exchange and other treatments.The clinical total ef-fective rate,alanine aminotransferase(ALT),serum total bilirubin(TBIL),serum albumin(ALB),blood urea nitro-gen(BUN),serum creatinine(Scr)and cystatin C(CysC),24 h urine volume,Na',K*levels were compared be-tween the two groups.Results:The difference in total effective rate between the two groups was not statistically significant(P>0.05).Affer treatment,the levels of ALT and TBIL in the two groups were significantly lower than those before treatment,and the levels of ALB were significantly higher than those before treatment.After treat-ment,the levels of ALT and TBIL in the observation group were significantly lower than those in the control group,and the levels of ALB were significantly higher than those in the control group(P<0.05).After treatment,the levels of BUN,Scr,CysC in the two groups were significantly lower than those before treatment,and the 24 h urine volume was significantly higher than before treatment(P<0.05).The levels of BUN,Scr,CysC in the obser-vation group were significantly lower than those in the control group,and the 24h urine volume was significantly higher than those in the control group(P<0.05).The levels of Nat and K*in the two groups after treatment were significantly higher than those before treatment,and the levels of Na'and K*in the observation group after treat-ment were significantly higher than those in the control group(P<0.05).Conclusion:Modifie

关 键 词：急性重型肝炎 肝肾综合征 胃苓散加味 人工肝 

分 类 号：R575.1[医药卫生—消化系统]