基于网络药理学探究复方金果胃康散治疗胃癌前病变的作用机制  

Investigation on the function mechanism of compound Jinguo Weikang Powder in the treatment of precancerous lesions of gastric cancer based on network pharmacology

作　　者：昝柏尧 宋健[1] 孟凯强 白鑫蔚 刘洛奇 胡紫娟 彭珍珍 王医 白宇雪 ZAN Baiyao;SONG Jian;MENG Kaiqiang;BAI Xinwei;LIU Luoqi;HU Zijuan;PENG Zhenzhen;WANG Yi;BAI Yuxue(Department of Traditional Chinese Medicine,the First Clinical Medical College of Shaanxi University of Chinese Medicine,Shaanxi,Xianyang 712046,China)

机构地区：[1]陕西中医药大学第一临床医学院中医系,陕西咸阳712046

出　　处：《中国医药科学》2023年第13期39-42,68,共5页China Medicine And Pharmacy

基　　金：陕西省大学生创新创业训练计划项目(S202110716040)。

摘　　要：目的运用网络药理学研究复方金果胃康散治疗胃癌前病变(PLGC)的作用机制。方法借助TCMSP数据库筛选复方金果胃康散的活性化学成分,并通过Swiss Target Prediction数据库检索各成分并预测靶点。通过GenCards数据库获取PLGC的靶点。通过String数据库蛋白互作网络(PPI)和Cytoscape 3.7.1软件绘制“药物-靶点”网络,采用Metascape平台进行GO、KEGG富集分析,获得复方金果胃康散治疗PLCG作用通路。结果获得复方金果胃康散活性成分85个,作用靶点338个。主要活性成分为槲皮素、β-谷甾醇等。PPI筛选后得到关键蛋白甘油醛-3-磷酸脱氢酶(GAPDH)、丝氨酸/苏氨酸蛋白激酶(AKT1)等。KEGG通路涉及微小核糖核酸(miRNA)通路、磷脂酰肌醇3-激酶/蛋白激酶(PI3K/AKt)信号通路等。结论初步验证了复方金果胃康散治疗PLCG的作用机制。Objective To investigate the function mechanism of compound Jinguo Weikang Powder in the treatment of precancerous lesions of gastric cancer(PLGC)using network pharmacology.Methods With the help of the TCMSP database,TCMID database and the chemical database of Shanghai Institute of Organic Chemistry,the active chemical components of compound Jinguo Weikang Powder were screened,and the components were retrieved by the Swiss Target Prediction database and the target was predicted.The target of PLGC was obtained through the GenCards database.The"drug-target"network was drawn by String database protein interaction network(PPI)and Cytoscape 3.7.1 software,and GO and KEGG enrichment analysis were conducted by the Metascape platform,and the function pathway of compound Jinguo Weikang powder in the treatment of PLCG was obtained.Results A total of 85 active components and 338 function targets were obtained.The main active ingredients were quercetin,β-sitosterol,etc.After PPI screening,key proteins such as glyceraldehyde-3-phosphate dehydrogenase(GAPDH)and serine/threonine protein kinase(AKT1)were obtained.KEGG pathway involved microribonucleic acid(miRNA)pathway and phosphatidylinositol 3-kinase/protein kinase(PI3K/AKt)signal pathway,etc.Conclusion The function mechanism of compound Jinguo Weikang powder in the treatment of PLCG was preliminarily verified.

关 键 词：复方金果胃康散 网络药理学 胃癌前病变 作用机制 

分 类 号：R730[医药卫生—肿瘤]