抑郁障碍住院患者全血细胞计数、甲状腺功能和性激素水平的回顾分析  

Retrospective analysis of complete blood count, thyroid function and sex hormone levels among inpatients with clinical depression

作　　者：翟思雨 郑玲 时萌萌 唐和斌[1] 李玉桑[1] 顾洪伟[1] ZHAI Si-yu;ZHENG Ling;SHI Meng-meng(Lab of Hepatopharmacology and Ethnopharmacology,School of Pharmaceutical Sciences,South-Central University for Nationalities,Wuhan 430074,China;不详)

机构地区：[1]中南民族大学药学院肝脏与民族药理学实验室,武汉430074 [2]武汉市精神卫生中心药学部,武汉430012

出　　处：《中国处方药》2023年第7期166-171,共6页Journal of China Prescription Drug

基　　金：湖北省卫健委联合基金项目(WJ2019H423);武汉市卫健委科研项目(WZ19A16)。

摘　　要：目的研究抑郁住院患者的全血细胞计数、甲状腺功能以及性激素水平与临床特征的关系。方法对武汉市精神卫生中心2017~2019年期间抑郁住院患者的人口学特征进行分析,并收集其血清生化检测指标,包括血小板计数(PLT)、中性粒细胞计数(NEU)、单核细胞计数(MON)、淋巴细胞计数(LYM)、单核细胞-淋巴细胞比值(MLR)、中性粒细胞-淋巴细胞比值(NLR)、血小板-淋巴细胞比值(PLR)、全身免疫-炎症指数(SⅢ)、促甲状腺激素(TSH)、游离甲状腺素(FT_(4))、游离三碘甲状腺原氨酸(FT_(3))、雌二醇(E_(2))、卵泡刺激素(FSH)、孕酮(P)、黄体生成素(LH)、泌乳素(PRL)、睾酮(T)。筛选符合《国际疾病分类(第十版)》(ICD-10)诊断标准的抑郁组患者2033例,并按抑郁程度分为轻中度抑郁发作组和重度抑郁发作组,选取同期210例体检者为健康组,分别比较健康组与抑郁组、轻中度抑郁发作组与重度抑郁发作组患者全血细胞计数、甲状腺功能、性激素水平的差异。结果抑郁障碍住院患者年均增长率为36.0%,18岁以下的未成年患者增长率最高,为220.2%。抑郁组患者的PLT、NLR、PLR和SⅢ水平高于健康组,LYM水平低于健康组,差异有统计学意义(P<0.05);重度抑郁发作组患者的MON、NEU、PLT、MLR、NLR、PLR和SⅢ水平高于轻中度抑郁发作组患者,差异有统计学意义(P<0.05)。抑郁组患者的TSH水平与健康组相比,差异无统计学意义(P>0.05),抑郁组男性和女性患者的FT_(4)水平均高于健康组,抑郁组女性患者的FT_(3)水平低于健康组,差异有统计学意义(P<0.05)。16~45岁抑郁组女性患者的LH、PRL水平高于健康组,差异有统计学意义(P<0.05)。结论抑郁患者体内免疫炎症的激活程度与抑郁的严重程度有着紧密的联系,可以作为抑郁患者病情的参考,临床诊治过程中要更加关注女性患者甲状腺功能和性激素水平变化情况。Objective To study the relationship between complete blood cell count,thyroid function,and sex hormone levels,and clinical characteristics in depressed hospitalized patients.Methods The demographic characteristics of depressed inpatients at Wuhan Mental Health Center during 2017~2019 were analyzed,and their serum biochemical tests were collected,including platelet count(PLT),neutrophit count(NEU),monocyte count(MON),lymphocyte count(LYM),monocyte-lymphocyte ratio(MLR),neutrophil-lymphocyte ratio(NLR),platelet-lymphocyte ratio(PLR),systemic immune inflammation index(SⅢ),thyroid stimulating hormone(TSH),free thyroxine(FT_(4)),free triiodothyronine(FT_(3)),estradiol(E_(2)),follicle stimulating hormone(FSH),progesterone(P),luteinizing hormone(LH),prolactin(PRL),testosterone(T)level.We screened 2,033 patients in the depression group who met the diagnostic criteria of the International Classification of Diseases(10th edition)(ICD-10),and divided them into mild to moderate depressive episode group and major depressive episode group according to the degree of depression,and selected 210 physical examiners in the same period as the healthy group,and compared the complete blood cell count,thyroid function,and sex hormone level between the healthy group and the depression group,and the mild to moderate depressive episode group and the major depressive episode group,respectively.Results The average annual growth rate of inpatients with depressive disorders was 36.0%,and the highest growth rate of 220.2%was observed in minor patients under 18 years of age.The levels of PLT,NLR,PLR,and SⅢwere higher in the depressed group than in the healthy group,and the levels of LYM were lower than that in the healthy group,and the differences were statistically significant(P<0.05);the levels of MON,NEU,PLT,MLR,NLR,PLR,and SⅢwere higher in the patients in the major depressive episode group than in the patients in the mild to moderate depressive episode group,and the differences were statistically significant(P<0.05).The TSH levels of

关 键 词：抑郁障碍 临床抑郁分型 全血细胞计数 甲状腺功能 性激素 

分 类 号：R749.4[医药卫生—神经病学与精神病学]